Results 41 to 50 of about 1,031,328 (268)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A review of studies of adherence with antihypertensive drugs using prescription databases. [PDF]

, 2005
Poor adherence with antihypertensive therapies is a major factor in the low rates of blood pressure control among people with hypertension. Patient adherence is influenced by a large number of interacting factors but their exact impact is not well ...
Fitz-Simon, Nicola, Feely, John, Bennett, Kathleen   +2 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Cohort study examining tamoxifen adherence and its relationship to mortality in women with breast cancer [PDF]

, 2008
Increasing duration of tamoxifen therapy improves survival in women with breast cancer but the impact of adherence to tamoxifen on mortality is unclear. This study investigated whether women prescribed tamoxifen after surgery for breast cancer adhered to
Crilly, M., C McCowan, Donnan, P.T., T P Fahey, McCowan, C., Shearer, J., Fahey, T. P., Thompson, A. M., P T Donnan, Donnan, P. T.; id_orcid, Dewar, J.A., Dewar, J. A., J A Dewar, A M Thompson, Thompson, A.M., Fahey, T.P., M Crilly, J Shearer   +17 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Adherence to antiretroviral therapy and treatment outcomes among conflict-affected and forcibly displaced populations: a systematic review. [PDF]

, 2012
BACKGROUND: Optimal adherence to highly active antiretroviral therapy (HAART) is required to promote viral suppression and to prevent disease progression and mortality.
Mendelsohn Joshua B, Mendelsohn, Joshua B, Spiegel, Paul, Schilperoord Marian, Schilperoord, Marian, Ross, David A, Spiegel Paul, Ross David A   +7 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

The therapeutic relationship and adherence to antipsychotic medication in schizophrenia [PDF]

, 2012
OBJECTIVE: Previous research has shown that a better therapeutic relationship (TR) predicts more positive attitudes towards antipsychotic medication, but did not address whether it is also linked with actual adherence.
McCabe, R, Hansson Lars, Svensson Bengt, Bullenkamp, J, Rössler, W, Martínez Leal, Rafael, Hansson, Lars, Torres-Gonzalez, F, Lauber, Christoph, Martinez-Leal, Rafael, Durk Wiersma, Roessler, W, Rössler, W., Priebe, Stefan, McCabe, R., Martinez-Leal, R., Svensson, Bengt, Torres González, Francisco, McCabe, Rosemarie, McCabe, Rose, Brink, Rob van den, Rosemarie McCabe, van den Brink Rob, Hansson, Lars,, Hansson, L., Rössler, Wulf, van den Brink, R., Martinez-Leal Rafael, Lars Hansson, Salize, HJ, van den Brink, Rob, Lauber, C., Martinez-Leal, R, Rafael Martinez-Leal, Wiersma Durk, Hans Joachim Salize, Lauber, C, Priebe, S, Lund University., Torres-Gonzalez Francisco, Wiersma, Durk, Torres-Gonzalez, Francisco, Wiersma, D, Rössler Wulf, Priebe, S., Christoph Lauber, Salize, H., Svensson, B., Wiersma, D., Svensson, Bengt,, Rob van den Brink, McCabe Rosemarie, Roessler, Wulf, Priebe Stefan, Jens Bullenkamp, Bullenkamp, J., Stefan Priebe, Francisco Torres-Gonzalez, Bullenkamp, Jens, Bullenkamp Jens, Hansson, L, Lauber Christoph, Salize Hans Joachim, van den Brink, R, Wulf Rössler, Salize, Hans Joachim, Svensson, B, Torres-Gonzalez, F., Bengt Svensson   +68 more
core   +1 more source