Results 61 to 70 of about 1,031,328 (268)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Therapeutic non adherence: a rational behavior revealing patient preferences ? [PDF]

This paper offers an indirect measure of patient welfare based on whether patients comply with the prescription they receive. Adherence behavior is supposed to reveal patients' subjective valuations of particular therapies.
Pierre-Yves Geoffard, Karine Lamiraud
core  

The AdHOC study of older adults' adherence to medication in 11 countries [PDF]

, 2005
Objective: Authors investigated, cross-nationally, the factors, including demographic, psychiatric ( including cognitive), physical, and behavioral, determining whether older people take their prescribed medication.
Cooper, Claudia, Katona, Cornelius, Cordula Wagner, Daniela Fialova, Wagner, C., Cornelius Katona, Wagner, Cordula, Livingston, G., Carpenter, G. Iain, Gill Livingston, Cooper, C., Katona, C., Fialova, Daniela, Carpenter, I., Schroll, M., Iain Carpenter, Claudia Cooper, Marianne Schroll, Livingston, Gill, Schroll, Marianne, Fialova, D.   +20 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Adherence to and effectiveness of Highly Active Antiretroviral Treatment for HIV infection: assessing the bidirectional relationship [PDF]

It is well-established that high adherence to HAART is a major determinant of virological and immunological success. Furthermore, psycho-social research has identified a wide range of adherence factors.
François Raffi, Bruno Spire, Maria Patrizia Carrieri, Christian Michelet, Luminita Schneider, Catherine Leport, Fidéline Collin, Karine Lamiraud, Jean-Paul Moatti, Camelia Protopopescu   +9 more
core  

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Understanding Processes, Outcomes, and Contexts in Medication Adherence: The Medication Adherence Context and Outcomes (MACO) Framework

, 2023
Poor medication adherence is a significant problem, yet interventions to improve it have been largely ineffective. Existing ecological models indicate that adherence is multi-dimensional; however, they do not reflect understanding of context-specific ...
Ruppar, Todd M., Bartlett Ellis, Rebecca J., Haase, Joan E.   +2 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

An exploratory study investigating factors associated with adherence to chest physiotherapy and exercise in adults with cystic fibrosis [PDF]

, 2009
Copyright @ 2009 European Cystic Fibrosis Society. This article is available through Elsevier's Open Access Archives and covered by Elsevier's user license: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user ...
Lynn B. Myers, Myers, Lynn B., Myers, LB
core   +1 more source