Results 71 to 80 of about 1,294,793 (306)

A review of studies of adherence with antihypertensive drugs using prescription databases. [PDF]

, 2005
Poor adherence with antihypertensive therapies is a major factor in the low rates of blood pressure control among people with hypertension. Patient adherence is influenced by a large number of interacting factors but their exact impact is not well ...
Fitz-Simon, Nicola, Feely, John, Bennett, Kathleen   +2 more
core   +1 more source

Understanding Processes, Outcomes, and Contexts in Medication Adherence: The Medication Adherence Context and Outcomes (MACO) Framework

, 2023
Poor medication adherence is a significant problem, yet interventions to improve it have been largely ineffective. Existing ecological models indicate that adherence is multi-dimensional; however, they do not reflect understanding of context-specific ...
Ruppar, Todd M., Bartlett Ellis, Rebecca J., Haase, Joan E., Joan E Haase, Todd M Ruppar, Rebecca J Bartlett Ellis   +5 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Clinical and economic consequences of medication nonadherence: a review of systematic reviews

Frontiers in Pharmacology
BackgroundMedication efficacy observed in clinical trials may differ from its effectiveness during real-world usage. Medication nonadherence is one of the key factors being responsible for this efficacy-effectiveness gap.
Maria Achterbosch, Nilay Aksoy, George D. Obeng, George D. Obeng, David Ameyaw, David Ameyaw, Tamás Ágh, Tamás Ágh, Job F. M. van Boven, Job F. M. van Boven   +9 more
doaj   +1 more source

Geriatric syndromes are potential determinants of the medication adherence status in prevalent dialysis patients

, 2017
Background. Geriatric syndromes (GS) exhibit high prevalence in patients with end-stage renal disease (ESRD) under chronic dialysis irrespective of age. We sought to determine whether GS influences medication adherence in ESRD patients. Methods.
Chao, Chia-Ter;Huang, Jenq-Wen, 趙家德;黃政文   +1 more
core   +1 more source

Good adherence to HAART and improved survival in a community HIV/AIDS treatment and care programme: the experience of The AIDS Support Organization (TASO), Kampala, Uganda. [PDF]

, 2008
BACKGROUND: Poor adherence to highly active antiretroviral therapy (HAART) may result in treatment failure and death. Most reports of the effect of adherence to HAART on mortality come from studies where special efforts are made to provide HAART under ...
Kalyango Joan N, Ekoru Kenneth, Todd Jim, Charles AS Karamagi, Levin, Jonathan, Karamagi, Charles AS, Andrew M Abaasa, Jonathan Levin, Ekoru, Kenneth, Abaasa Andrew M, Abaasa, Andrew M, Levin Jonathan, Joan N Kalyango, Odeke Emmanuel, Emmanuel Odeke, Todd, Jim, Karamagi Charles AS, Kalyango, Joan N, Odeke, Emmanuel, Jim Todd, Kenneth Ekoru   +20 more
core   +2 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Taking a broader perspective on medication adherence : the importance of system factors [PDF]

, 2011
As behavior is influenced by the system in which the patient lives, it is crucial to investigate the role of system factors in explaining adherence.
Berben, Lut
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source