Results 91 to 100 of about 705,905 (266)
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Research on Active Anti-Slip Control of High-Speed Trains Based on High-Order Sliding Mode
Applied SciencesThis paper addresses the issue of wheelset slip in trains caused by low-adhesion track surfaces and proposes an active anti-slip tracking control strategy.
Song Wang +3 more
doaj +1 more source
Click Decoration of Bombyx mori Silk Fibroin for Cell Adhesion Control. [PDF]
Molecules, 2020 Teramoto H, Shirakawa M, Tamada Y.
europepmc +1 more source
Actin adhesion controls bacterial movement
The Journal of Cell Biology, 2005 Actin comet tails propel bacteria through their host cells. Now, Frederick Soo (University of Washington, Seattle, WA) and Julie Theriot (Stanford University, Stanford, CA) suggest that a bug's speed is determined by adhesion between actin and bacterium, not rates of actin polymerization.
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Adhesion Utilization Control of SDA1 AC Drive Diesel Locomotive Based on Speed Radar
机车电传动, 2012 According to the high requirements on adhesion utilization control performance of SDA1 AC drive diesel locomotive, a scheme of adhesion utilization control based on speed radar was presented, principle and realization approach of which was introduced ...
CHEN Hua-guo +3 more
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source