Results 81 to 90 of about 705,905 (266)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
机车电传动, 2016 The adhesion control technical level of the new generation electric locomotive made in China represented by Shenhua and20E locomotive for South Africa was introduced.
QIU Zirong +2 more
doaj
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Infection and Drug Resistance, 2019 Gabrielle Messias De Souza, Estevan Rodrigues Dos Santos Neto, Alaor Martins da Silva, Maria Vitoria Minzoni de Souza Iacia, Marcus Vinícius Pimenta Rodrigues, Valéria Cataneli Pereira, Lizziane Kretli Winkelstroter Health Sciences Faculty,
Souza GM +6 more
doaj
PLoS ONE, 2019 Postoperative adhesion is a natural phenomenon that occurs in damaged tissue cells. Several anti-adhesion agents are currently used, but there is no leading-edge product with excellent adhesion-preventive effects. The purpose of this study was to develop
Jong Ju Jeong +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Research and Application of Adhesion Utilization Control for High Power AC Freight Locomotive HXD1C
机车电传动, 2011 Introduction was given to the adhesion utilization control system of the high power AC locomotive HXD1C. And field sampled data of the adhesion utilization control for the locomotive HXD1C were fully analyzed, which demonstrates the effectiveness of the ...
李江红 +4 more
doaj
Abstract and Applied Analysis, 2014 Train traction/braking control, one of the key enabling technologies for automatic train operation, literally takes its action through adhesion force. However, adhesion coefficient of high speed train (HST) is uncertain in general because it varies with ...
Wenchuan Cai +3 more
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source