Results 101 to 110 of about 6,033 (284)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

Advanced Science, EarlyView.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai, Siying Cheng, Fengguang Ma, Xiaorong Zhang, Jianan Huang, Zhonghua Liu, Bing Hu   +6 more
wiley   +1 more source

A framework for conducting GWAS using repeated measures data with an application to childhood BMI

Nature Communications
Genetic effects on changes in human traits over time are understudied and may have important pathophysiological impact. We propose a framework that enables data quality control, implements mixed models to evaluate trajectories of change in traits, and ...
Kimberley Burrows, Anni Heiskala, Jonathan P. Bradfield, Zhanna Balkhiyarova, Lijiao Ning, Mathilde Boissel, Yee-Ming Chan, Philippe Froguel, Amelie Bonnefond, Hakon Hakonarson, Alexessander Couto Alves, Deborah A. Lawlor, Marika Kaakinen, Marjo-Riitta Järvelin, Struan F. A. Grant, Kate Tilling, Inga Prokopenko, Sylvain Sebert, Mickaël Canouil, Nicole M. Warrington   +19 more
doaj   +1 more source

Impact of the Great East Japan Earthquake on Body Mass Index, Weight, and Height of Infants and Toddlers: An Infant Survey

Journal of Epidemiology, 2018
Background: The body mass index (BMI) of preschool children from 4 years of age through primary school has increased since the Great East Japan Earthquake, but that of children aged under 3 years has not been studied.
Hiroshi Yokomichi, Hiroko Matsubara, Mami Ishikuro, Masahiro Kikuya, Tsuyoshi Isojima, Susumu Yokoya, Noriko Kato, Toshiaki Tanaka, Shoichi Chida, Atsushi Ono, Mitsuaki Hosoya, Soichiro Tanaka, Shinichi Kuriyama, Shigeo Kure, Zentaro Yamagata   +14 more
doaj   +1 more source

Environment and Obesity in the National Children\u27s Study [PDF]

, 2009
Objective: In this review we describe the approach taken by the National Children’s Study (NCS), a 21-year prospective study of 100,000 American children, to understanding the role of environmental factors in the development of obesity.
Carrel, Aaron L, Cronk, Christine E., Durkin, Maureen S., Gall, Elizabeth A, Gillman, Matthew W, Hewitt, Jeanne B, Landrigan, Philip J, Schoeller, Dale A, Trasande, Leonardo, Weiss, Marianne E.   +9 more
core   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

Individual, behavioural and environmental pathways to adolescent obesity [PDF]

, 2010
The longitudinal investigations of the contributions of obesogenic variables to developmental pathways of adolescent obesity were examined. Key obesogenic variables were examined from the extensive database of the Western Australian Pregnancy Cohort ...
Chivers, Paola Teresa
core   +1 more source

Leptin in early life: A key factor for the development of the adult metabolic profile [PDF]

, 2012
Leptin levels during the perinatal period are important for the development of metabolic systems involved in energy homeostasis. In rodents, there is a postnatal leptin surge, with circulating leptin levels increasing around postnatal day (PND) 5 and ...
Argente, Jesús, Chowen, Julie Ann, Fuente-Martín, Esther, García-Cáceres, Cristina, Granado, Miriam   +4 more
core   +2 more sources

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

Percentile reference values for anthropometric body composition indices in European children from the IDEFICS study [PDF]

, 2014
INTRODUCTION: To characterise the nutritional status in children with obesity or wasting conditions, European anthropometric reference values for body composition measures beyond the body mass index (BMI) are needed.
A Lanfer, A Sarrıa, A Sarría, A Siani, ACR Adaki, AM Frideriks, AV Khadilkar, AW Sloan, C Buck, CM de Ridder, D Molnár, DM Stasinopoulos, DR Silva, DS Freedman, E Kovacs, F Lauria, G Rose, GA Bray, GM Haas, H Mellerio, HD McCarthy, HP Chang, I Pigeot, I Sioen, J Revenga-Frauca, JA Westrate, JC Eisenmann, JC Wells, JC Wells, JCK Wells, JCK Wells, JH Wilmore, JR Fernandez, JV Durnin, K Bammann, KR Laurson, L A Moreno, L Lissner, LA Moreno, LA Moreno, LA Moreno, LA Moreno, M Claessens, M Jawrowski, M Shields, M Tornaritis, MEJ Lean, MH Slaughter, MM Maziczioglu, MS Treuth, N Hatipoglu, N Hatipoglu, OO Nafiu, OY Addo, P Brambilla, P Brambilla, P Deurenberg, P Nagy, P Scwandt, RA Rigby, RJ Kuczmarski, RYT Sung, S Mårild, S Stomfai, S van Buuren, SC Savva, SR Srinivasan, SV Galcheva, T Intemann, T Veidebaum, TJ Cole, TJ Cole, W Ahrens, W Ahrens, Wells JCK, WHO Multicentre Growth Reference Study Group, Y Kourides, YM Abdulrazzaq   +77 more
core   +2 more sources