Results 111 to 120 of about 1,364,020 (299)
Early Adjacent Segment Degeneration after Short Lumbar Fusion
Global Spine Journal, 2016 Introduction Today in a review of the world literature there is no consensus about the main risk factor for the symptomatic adjacent segment disease, as well as the terms and conditions of its occurrence.
Sergei Masevnin +5 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Global Spine Journal, 2015 Introduction Adjacent segment degeneration or disease (ASD or ASDs) has been one of the most concerned issues after fusion of the lumbar spine. To investigate the radiographical and clinical outcome of adjacent segment degeneration after topping-off ...
Yong Hai, Xiaolong Chen
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Does anterior plating of the cervical spine predispose to adjacent segment changes?
, 2005 Study Design. In a human cadaveric model, the effects of plate supplementation on the mechanical behaviors of adjacent segments were investigated. Objectives.
Kenny S. David +9 more
core +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
The TerraSAR-X Ground Segment [PDF]
, 2006 The Ground Segment of the TerraSAR-X mission provides the infrastructure required to command and control the satellite and the instrument, to receive user requests, to process and archive the acquired data and to deliver the image products.
Werninghaus, Rolf +4 more
core