Results 121 to 130 of about 1,364,020 (299)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Segment angles as a function of time.

open access: yes, 2014
Angles between adjacent segments of the four-segment anatomical model over a full cycle. Squares represent the four-segment anatomical model and lines represent the four-segment anatomical Fourier model.
Alex A. Villanueva (679351)   +1 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

The Effect of Fusion on the Adjacent Segment Motion in a Lumbar Spine

open access: yes, 2014
Back Pain is one of the most prevalent work related injuries in the United States. It has been shown that heavy physical work, and injuries in addition to other physiological conditions cause back pain.
Mruga Patel (7980668)
core   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Adjacent Segment Degeneration (ASD) Following Lumber Arthrodesis; Risk Factors and Management.

open access: yes, 2013
Background Data: Spinal bony fusion is considered to be a good method for treating deformity, trauma, and degenerative lesions. Fusion rates have a good outcome due to improvements in instrumented fixation and bone graft sources.
Mohammed Eshra
core   +1 more source

ALTERATION OF PELVIC PARAMETERS IN ADJACENT SEGMENT DEGENERATION

open access: yesColuna/Columna
Objective: To describe the changes in the spino-pelvic parameters obtained after lumbar spine surgery. Methods: Prospective study. Results: The post-surgical pelvic parameters were found as follows: pelvic incidence of 75.75°, sacral slope 46.18 ...
Carla Lisette García Ramos   +1 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

The spondylolytic vertebra and its adjacent segment. Mobility measured before and after posterolateral fusion

open access: yes, 1997
STUDY DESIGN: By using roentgen stereophotogrammetric analysis in six patients having tantalum indicators implanted at a preoperative external fixation test, the mobility in the spondylolytic lumbosacral level and its adjacent segment could be studied ...
Johnsson, Ragnar,   +3 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

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