Results 61 to 70 of about 1,364,020 (299)

Cervical Disc Arthroplasty and Adjacent Segment Pathology

Global Spine Journal, 2014
The advantages of arthroplasty include maintenance of motion, avoiding nonunions, and avoiding plate and screw complications such as backout, esophageal erosion, and periplate ossification.
K. Daniel Riew
doaj   +1 more source

Adjacent segment level disease in Klippel-Feil syndrome patients with congenital cervical fusion in the setting of anterolisthesis: Should management be altered in the presence of anterolisthesis?

Translational Research in Anatomy, 2017
Objective: The goal of our study was to determine the incidence of adjacent segment level pathology preoperatively in patients with Klippel-Feil syndrome (KFS) and compare it to the incidence in patients who have undergone anterior cervical discectomy ...
Fernando Alonso, Joe Iwanaga, Christian Fisahn, Koichi Watanabe, Elias Rizk, Joshua Chern, Rod J. Oskouian, R. Shane Tubbs, W. Jerry Oakes   +8 more
doaj   +1 more source

Complex neuroimaging study of the proximal segment after rigid fixation and dynamic stabilization in patients with degenerative lumbar disease

Acta Biomedica Scientifica, 2023
Background. The development of the adjacent level syndrome and, as a consequence, adjacent segment degenerative disease are currently the most common complications of decompression and stabilization surgery with the development of segmental instability ...
A. E. Krivosсhein, S. V. Kolesov, A. A. Kalinin, V. P. Konev, A. I. Kazmin, S. N. Moskovskiy, V. A. Byvaltsev   +6 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

ALTERATION OF PELVIC PARAMETERS IN ADJACENT SEGMENT DEGENERATION

, 2018
Objective: To describe the changes in the spino-pelvic parameters obtained after lumbar spine surgery. Methods: Prospective study. Results: The post-surgical pelvic parameters were found as follows: pelvic incidence of 75.75°, sacral slope 46.18 ...
Alejandro Reyes Sánchez (5631041), Carla Lisette García Ramos (5631038)   +1 more
core   +1 more source

Adjacent Segment Degeneration and Adjacent Segment Disease: Implications following Spinal Fusion Surgery

SVOA Neurology
Spinal fusion is a common and effective option for patients with symptomatic degenerative disc disorders. However, concerns have raised over the probability of adjacent segment degeneration (ASDe) and adjacent segment disease (ASDi) following spinal instrumentation.
Neda Kamandi, Mehran Ekrami, Mohsen Khamoushi, Samin Safarian, Alireza Davoudi, Amirmohammad Soleimanian, Asef Yoonesi, Daniel Kheradmand, Melika Payrovedin, Seyed Ali Shariat Razavi, Masoumeh Taghdisi, Amirhossein Beheshtdoost, Mohammad Reza Boustani, Nima Nabavi   +13 more
openaire   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source