Results 81 to 90 of about 1,364,020 (299)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Rigid fixation of the lumbar spine alters the motion and mechanical stability at the adjacent segment level

, 2014
Objectives: This study aims to examine the motion and stability of the adjacent segment following rigid fixation of the lumbar ...
KARAKAŞLI, AHMET, HAPA, ONUR, Taylan, Orcun, ERDURAN, MEHMET, ÇEÇEN, BERİVAN, HAVITÇIOĞLU, HASAN   +5 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Reference intervals of adjacent disc height in fresh osteoporotic vertebral compression fractures and the association with postoperative adjacent segment complications: a quantitative study in Chinese postmenopausal women

Journal of Orthopaedic Surgery and Research
Background Preoperative adjacent disc height (DH) was found as an independent risk factor for adjacent segment degeneration (ASD) after percutaneous kyphoplasty (PKP), indicating the preoperative status of the adjacent intervertebral discs may be closely
Ruiyuan Chen, Tianyi Wang, Ning Fan, Aobo Wang, Lei Zang, Shuo Yuan   +5 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

An upper bound computational model for investigation of fusion effects on adjacent segment biomechanics of the lumbar spine

, 2019
Prediction of the biomechanical effects of fusion surgery on adjacent segments is a challenge in computational biomechanics of the spine. In this study, a two-segment L3-L4-L5 computational model was developed to simulate the effects of spinal fusion on ...
Thomas Cha (5965637), Chaochao Zhou (6943709), Guoan Li (809504)   +2 more
core   +1 more source

The Relationship Between Postoperative Variation of Adjacent Segment Three‐Dimensional Kinematics and Postoperative PI‐LL in Patients With Degenerative Lumbar Scoliosis After Short Segment Fixation

Orthopaedic Surgery
Objective The etiology of adjacent segment diseases and proximal junctional kyphosis has been related to biomechanical alterations after spinal operation.
Fei Xu, Shuai Jiang, Zhuoran Sun, Nanfang Xu, Zheyu Fan, Siyu Zhou, Yudong Zhao, Zhuofu Li, Weishi Li   +8 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Biomechanical analysis of adjacent segments after correction surgery for adult idiopathic scoliosis: a finite element analysis

Scientific Reports
The biomechanical aspects of adjacent segment degeneration after Adult Idiopathic Scoliosis (AdIS) corrective surgery involving postoperative changes in motion and stress of adjacent segments have yet to be investigated.
Dong-hai Wang, Dan-ni Wu, Da-qi Xin, Qin Shi, Wen-xuan Wang, Wen-hua Xing, Hui-lin Yang   +6 more
doaj   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source