Results 111 to 120 of about 228,749 (323)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Word sense disambiguation criteria: a systematic study

open access: yes, 2004
This article describes the results of a systematic in-depth study of the criteria used for word sense disambiguation. Our study is based on 60 target words: 20 nouns, 20 adjectives and 20 verbs.
Audibert, Laurent
core   +2 more sources

Is the scope of phonological planning constrained by the syntactical role of the utterance constituents? [PDF]

open access: yes, 2009
Five experiments looked the effect of repeated phonemes in the production of color adjective+noun phrases in English ("green gun"), or noun+color adjective phrases in Spanish and French.
Damian, Markus   +3 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

The usage of simple Arabisms in “Khamsa” by Khoju Kirmoni (on the example of adjective)

open access: yesStudia Humanitatis, 2022
The article dwells on the issue concerned with the level of usage of some simple Arabisms in “Khamsa” by Khoju Kirmoni on the example of adjective. It is underscored that the borrowing of foreign words and the transfer of linguistic elements from one ...
Dodokhojaeva Parvinakhon Ikromovna
doaj  

Enrichment of OntoSenseNet: Adding a Sense-annotated Telugu lexicon

open access: yes, 2018
The paper describes the enrichment of OntoSenseNet - a verb-centric lexical resource for Indian Languages. This resource contains a newly developed Telugu-Telugu dictionary. It is important because native speakers can better annotate the senses when both
Parupalli, Sreekavitha, Singh, Navjyoti
core   +1 more source

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