Results 111 to 120 of about 218,273 (293)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Thumbs up or thumbs down? Semantic orientation applied to unsupervised classification of reviews [PDF]

open access: yes, 2002
This paper presents a simple unsupervised learning algorithm for classifying reviews as recommended (thumbs up) or not recommended (thumbs down). The classification of a review is predicted by the average semantic orientation of the phrases in the review
Turney, Peter D.
core   +4 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Hawking Hyphens in Compound Modifiers [PDF]

open access: yes, 2014
The first principle of legal writing is surely its clarity — visible actors (unless the action matters more), uncluttered syntax, and, of course, logical structure.
Magat, Joan Ames
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Human appearance and nature features exemplified by English compound adjectives [PDF]

open access: yes, 2014
The article deals with compound English adjectives defining person’s appearance and character. The role of word-composition and affixation is defined. In the article the compound adjectives have been considered semantically according to the connection ...
Baghana, J., Kravchenko, O. N.
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Syntax of Dutch: Adjectives and Adjective Phrases

open access: yes
Syntax of Dutch, a major linguistic research project currently based at the Meertens Institute Amsterdam, will be published in at least seven volumes over the period 2012-2016. The work is co-authored and edited by Hans Broekhuis. The aim of this publication is to present a synthesis of the available knowledge of Dutch syntax. It is primarily concerned
openaire   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Unmerging analytic comparatives [PDF]

open access: yes, 2018
We look at the internal structure of the English analytic comparative marker more, arguing that it spells out nearly all the features of a gradable adjective.
De Clercq, Karen, Vanden Wyngaerd, Guido
core  

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