Results 81 to 90 of about 490,563 (284)

Association of N-terminal pro-brain natriuretic peptide with cognitive function and depression in elderly people with type 2 diabetes [PDF]

, 2012
<p>Background: Type 2 diabetes mellitus is associated with risk of congestive heart failure (CHF), cognitive dysfunction and depression. CHF itself is linked both to poor cognition and depression.
,, Deary, Ian, Feinkohl, Insa, Price, Jackie F., Reynolds, Rebecca M., Sattar, Naveed, Strachan, Mark W. J., Welsh, Paul   +7 more
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Managing the dual challenge: Mood disorders in a patient with multidrug-resistant tuberculosis

BLDE University Journal of Health Sciences
Multidrug-resistant tuberculosis (MDR-TB) is defined as resistance to isoniazid and rifampicin, with or without resistance to other anti-TB drugs. Drug-resistant TB requires a long course of treatment with multiple drugs depending on drug sensitivity ...
S. Shyam, Keertivardhan D. Kulkarni, Saurav Suresh   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Prevalence of depression, anxiety, adjustment disorders, and somatoform disorders in patients with age-related macular degeneration in Germany

GMS German Medical Science, 2017
Aims: The purpose of this study was to analyze the prevalence of depression, anxiety, adjustment disorders, and somatoform disorders in patients diagnosed with age-related macular degeneration (AMD) in Germany.Methods: This study included 7,580 patients ...
Jacob, Louis, Spiess, Alexandra, Kostev, Karel   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Stress-related disorders in parents of children with cancer at the stage of hospital treatment

Консультативная психология и психотерапия, 2014
The purpose of this study was to investigate the psychopathological features of post-traumatic stress symptoms and the role of some psychosocial factors in the formation of adjustment disorders in parents of childhood cancer patients in hospital.
Koren E.V., Masikhina S.N.
doaj  

Breathing Signature as Vitality Score Index Created by Exercises of Qigong: Implications of Artificial Intelligence Tools Used in Traditional Chinese Medicine. [PDF]

, 2019
Rising concerns about the short- and long-term detrimental consequences of administration of conventional pharmacopeia are fueling the search for alternative, complementary, personalized, and comprehensive approaches to human healthcare.
Dethlefs, Brent A, Lee, Katherine L, Li, Shengwen Calvin, Loudon, William G, Luo, Jane, Su, Qingning, Zhang, Junjie   +6 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Workplace gender composition and long‐term sickness absence due to mental disorders: A retrospective cohort study

PCN Reports
Aim Long‐term sickness absence (LTSA) due to mental disorders is a public health concern. Workplace gender composition may influence employees' mental health outcomes; however, its impact on LTSA remains unclear.
Shohei Okura, Shinichi Iwasaki, Yasuhiko Deguchi, Yuki Kageyama, Kunio Maekubo, Ayaka Matsunaga, Koki Inoue   +6 more
doaj   +1 more source