Results 1 to 10 of about 949,522 (120)

Hormonal and inflammatory signatures of different mood episodes in bipolar disorder: a large-scale clinical study

BMC Psychiatry, 2023
Background Bipolar disorder (BD) is characterized by intensive mood fluctuations. While hormones imbalance plays important role in the mood swings, it is unknown whether peripheral hormones profiles could differentiate the manic and depressive mood ...
Nan Lyu, Qian Zhao, Bingbing Fu, Jinhong Li, Han Wang, Fan Yang, Sitong Liu, Juan Huang, Xinwei Zhang, Ling Zhang, Rena Li   +10 more
doaj   +1 more source

Multi-omics reveal microbial determinants impacting the treatment outcome of antidepressants in major depressive disorder

Microbiome, 2023
Background There is a growing body of evidence suggesting that disturbance of the gut-brain axis may be one of the potential causes of major depressive disorder (MDD).
Yaping Wang, Jingjing Zhou, Junbin Ye, Zuoli Sun, Yi He, Yingxin Zhao, Siyu Ren, Guofu Zhang, Min Liu, Peng Zheng, Gang Wang, Jian Yang   +11 more
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Effect of transcranial direct current stimulation with concurrent cognitive performance targeting posterior parietal cortex vs prefrontal cortex on working memory in schizophrenia: a randomized clinical trial

Translational Psychiatry
Working memory deficits are linked to irregularities in the dorsolateral prefrontal cortex (DLPFC) and the posterior parietal cortex (PPC) in schizophrenia, effective intervention strategies are lacking.
Wenpeng Hou, Fuchun Zhou, Qi Wang, Hang Li, Xiangqin Qin, Yushen Ding, Fang Dong, Qijing Bo, Anning Li, Liang Zhang, Zhenzhu Chen, Zhimin Wang, Xianbin Li, Jimmy Lee, Chuanyue Wang   +14 more
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Predicting antidepressant response via local-global graph neural network and neuroimaging biomarkers

npj Digital Medicine
Depressed mood and anhedonia, the core symptoms of major depressive disorder (MDD), are linked to dysfunction in the brain’s reward and emotion regulation circuits.
Rui Liu, Ximan Hou, Shuyu Liu, Yuan Zhou, Jingjing Zhou, Kaini Qiao, Han Qi, Ruinan Li, Zhi Yang, Ling Zhang, Jian Cui, Cheng Jin, Aihong Yu, Gang Wang   +13 more
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Peripheral NMDAR subunits as predictors of working memory improvement in schizophrenia

Schizophrenia
Cognitive dysfunction is a defining characteristic impairing social functioning in schizophrenia (SZ). N-methyl-D-aspartate receptor (NMDAR) hypofunction may underlie these impairments.
Xiangqin Qin, Wenpeng Hou, Zhen Mao, Hang Li, Qi Wang, Yushen Ding, Lige Ge, Fuchun Zhou, Qijing Bo, Xianbin Li, Chuanyue Wang, Fang Dong   +11 more
doaj   +1 more source

Association of hypertension and depression with mortality: an exploratory study with interaction and mediation models

BMC Public Health
Background The association of hypertension and depression with mortality has not been fully understood. We aimed to explore the possible independent or joint association of hypertension and depression with mortality.
Huanhuan Huang, Fanchao Meng, Yanjie Qi, Xiuping Yan, Junhui Qi, Yuanzhen Wu, Yiwei Lin, Xu Chen, Fan He   +8 more
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Post-specific difference in mental health among medical staff in Beijing during COVID-19 epidemic: an online survey

Zhongguo gonggong weisheng, 2023
ObjectiveTo analyze the difference in mental health status among medical staff working at different posts in Beijing city during coronavirus disease 2019 (COVID-19) epidemic.
Yinqi LIU, Zhe WANG, Chunjie ZHANG
doaj   +1 more source

Bilateral association between muscle strength and depression: evidence from a prospective cohort study

BMC Public Health
Background Both low muscle strength and depressive symptoms are common among middle-aged and older adults. However, their bilateral association has not been thoroughly investigated.
Tong Guo, Fanchao Meng, Sixiang Liang, Guangwei Zhao, Jun Liu, Xue Wang, Ling Zhang, Gang Wang   +7 more
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Shared and unique alterations of large-scale network connectivity in drug-free adolescent-onset and adult-onset major depressive disorder

Translational Psychiatry
Differences in clinical manifestations and biological underpinnings between Major Depressive Disorder (MDD) onset during adolescence and adulthood have been posited in previous studies, implying an influential role of age of onset (AOO) in the clinical ...
Ximan Hou, Rui Liu, Yuan Zhou, Lin Guan, Jingjing Zhou, Jing Liu, Mengqi Liu, Xiaofei Yuan, Yuan Feng, Xu Chen, Aihong Yu   +10 more
doaj   +1 more source

High testosterone levels associated with elevated suicidal risk in male adolescents with depression

BMC Psychiatry
Background Adolescent suicide, as a public health issue, is becoming increasingly urgent, yet there remains a lack of effective objective biomarkers for identifying high-risk adolescents.
Han Wang, Nan Lyu, Juan Huang, Bingbing Fu, Lili Shang, Fan Yang, Ling Zhang, Qian Zhao   +7 more
doaj   +1 more source