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LancetThe hallmark of bipolar disorder is hypomania or mania, and the predominant phase of illness is depression. Affecting approximately 40 million individuals worldwide, bipolar disorder is associated with a substantial psychosocial, medical, and financial burden and increased mortality from suicide and other causes.
Singh B +9 more
europepmc +5 more sources
Depression Research and Treatment, 2012 Bipolar disorder is a serious disorder of mood that is associated with considerable psychosocial and economic morbidity. Even though it is more common than previously thought, it has until relatively recently been somewhat neglected in terms of research when compared to disorders such as schizophrenia and major depression. Recent advances in the fields
COLOMBO , CRISTINA ANNA +2 more
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Frontiers in Psychiatry, 2023 BackgroundWe aimed to explore the predictive role of serum BDNF and anxiety-related variables in changes in somatic symptoms post-escitalopram treatment in panic disorder (PD) patients.MethodsNinety PD patients and 99 healthy controls (HCs) were enrolled.
Jiaxin Li +5 more
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Diagnostic Stability of Primary Psychotic Disorders in a Research Sample
Frontiers in Psychiatry, 2021 Psychiatric diagnosis is often treated as a stable construct both clinically and in research; however, some evidence suggests that diagnostic change may be common, which may impact research validity and clinical care.
Andrea J. Wood +7 more
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Structured physical exercise for bipolar depression: an open-label, proof-of concept study
International Journal of Bipolar Disorders, 2023 Background Physical exercise (PE) is a recommended lifestyle intervention for different mental disorders and has shown specific positive therapeutic effects in unipolar depressive disorder.
Beny Lafer +6 more
doaj +1 more source
Nature Reviews Disease Primers, 2018 Bipolar disorders are chronic and recurrent disorders that affect >1% of the global population. Bipolar disorders are leading causes of disability in young people as they can lead to cognitive and functional impairment and increased mortality, particularly from suicide and cardiovascular disease. Psychiatric and nonpsychiatric medical comorbidities are
Vieta, Eduard +8 more
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Translational Psychiatry, 2023 There is a gap in knowledge regarding the polygenic underpinnings of brain anomalies observed in youth bipolar disorder (BD). This study examined the association of a polygenic risk score for BD (BD-PRS) with grey matter structure and white matter ...
Xinyue Jiang +8 more
doaj +1 more source
BMC Psychiatry, 2021 Background The aim was to explore the associations between clinical symptoms, demographic variables, social and neurocognitive functioning in euthymic patients with bipolar disorder (BD) stratified by subgroups of DSM-IV BD (type I (BD-I) and type II (BD-
Xinyu Liu +6 more
doaj +1 more source
NeuroImage: Clinical, 2021 Background: Auditory hallucinations (AH) are typically associated with schizophrenia (SZ), but they are also prevalent in bipolar disorder (BD). Despite the large body of research on the neural correlates of AH in SZ, the pathophysiology underlying AH ...
Melissa Hwang +7 more
doaj +1 more source
International Journal of Bipolar Disorders, 2023 Background CACNA1C rs1006737 A allele, identified as a genetic risk variant for bipolar disorder (BD), is associated with anomalous functional connectivity in adults with and without BD.
Xinyue Jiang +6 more
doaj +1 more source