Results 181 to 190 of about 304,312 (247)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Clinical utility and psychometric validity of the International Adjustment Disorder Questionnaire in a sample of South African working adults. [PDF]

S Afr J Psychiatr
van Wijk CH, Muller CJB, Andrews BN.
europepmc   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Metabolomic ageing across mental and behavioural disorders. [PDF]

BMJ Ment Health
Mutz J, Gilchrist L, Allegrini AG, Sanchez Roige S, Lewis CM.   +4 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Pre-diagnostic biomarkers and risk of stress-related disorders: a cohort study based on electronic health records. [PDF]

BMC Med
Peltola AA, Khan E, Tirkkonen A, von Bonsdorff MB, Jylhävä J, Lin J.   +5 more
europepmc   +1 more source

Trends in the diagnostic prevalence of cannabis-related disorders and co-occurring psychiatric disorders in adolescents: analysis of German health insurance data from 2013 to 2022. [PDF]

Eur J Public Health
Zarour A, Bachmann C, Dandolo L, Holstiege J, Hoffmann F, Scholman C, Golub Y.   +6 more
europepmc   +1 more source

Anhedonia and Anxious Arousal Are Associated With Distinct Expectations About the Statistics of a Volatile Environment. [PDF]

Biol Psychiatry Glob Open Sci
Duda JM, Cannon TD, Paskewitz S, Palmer WC, Suthaharan P, Kenney JG, Corlett PR, Joormann J.   +7 more
europepmc   +1 more source