Results 101 to 110 of about 809,966 (374)
Principal causal effect identification and surrogate endpoint evaluation by multiple trials [PDF]
arXiv, 2015 Principal stratification is a causal framework to analyze randomized experiments with a post-treatment variable between the treatment and endpoint variables. Because the principal strata defined by the potential outcomes of the post-treatment variable are not observable, we generally cannot identify the causal effects within principal strata. Motivated
arxiv
Adjuvant Therapy: Melanoma [PDF]
Journal of Skin Cancer, 2011 With an incidence that is increasing at 2–5% per year, cutaneous melanoma is an international scourge that disproportionately targets young individuals. Despite much research, the treatment of advanced disease is still quite challenging. Immunotherapy with high-dose interferon-α2b or interleukin-2 benefits a select group of patients in the adjuvant and
Diwakar Davar +2 more
openaire +3 more sources
Adjuvant Therapy Reduces Rate of Dissemination but Shortens Survival Thereafter.
The Oncologist, 2015 We thank Xu et al. [1] for their answer to our letter [2] concerning the publication of Seidman et al. [3]; however, they may have misunderstood our letter, assuming a contradiction to classical papers of Bonadonna et al.
Michael K Fink +2 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee +5 more
wiley +1 more source
Scientific Reports, 2017 In an effort to reduce the frequency and severity of adverse reactions seen from the use of mineral oil adjuvants in salmonid fish, the effects of two alternative adjuvants were assessed, focusing on the induction of adverse effects as well as protection.
Kasper Rømer Villumsen +3 more
doaj +1 more source
Vaccines, 2019 Zika virus (ZIKV) is a flavivirus similar to Dengue virus (DENV) in terms of transmission and clinical manifestations, and usually both viruses are found to co-circulate.
Gustavo Cabral-Miranda +9 more
doaj +1 more source
Novel digital tissue phenotypic signatures of distant metastasis in colorectal cancer [PDF]
arXiv, 2018 Distant metastasis is the major cause of death in colorectal cancer (CRC). Patients at high risk of developing distant metastasis could benefit from appropriate adjuvant and follow-up treatments if stratified accurately at an early stage of the disease.
arxiv
Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer
New England Journal of Medicine, 2018 BACKGROUND In the Suppression of Ovarian Function Trial (SOFT) and the Tamoxifen and Exemestane Trial (TEXT), the 5‐year rates of recurrence of breast cancer were significantly lower among premenopausal women who received the aromatase inhibitor ...
P. Francis +35 more
semanticscholar +1 more source
International Journal of Gynecological Cancer, 2020 Background Vaginal brachytherapy is currently recommended as adjuvant treatment in patients with high-intermediate risk endometrial cancer to maximize local control and has only mild side effects and no or limited impact on quality of life.
A. S. V. M. van den Heerik +29 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren +8 more
wiley +1 more source