Results 131 to 140 of about 809,966 (374)

Improving organ dose sparing in left‐sided breast cancer with yaw‐limited volumetric modulated arc therapy: A dosimetric comparison to conventional and intensity modulated radiation therapy approaches

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background To assess the dose‐sparing capabilities of a yaw‐limited volumetric modulated arc therapy (YL_VMAT) beam setup for adjacent organs at risk (OAR) in comparison with 3D‐conventional radiation therapy (3D‐CRT), intensity‐modulated radiation therapy (IMRT) and conventional VMAT for radiation therapy in left‐sided breast cancer patients.
Gerhard Pollul, Sascha Grossmann, Heiko Karle, Tilman Bostel, Heinz Schmidberger   +4 more
wiley   +1 more source

On null hypotheses in survival analysis [PDF]

arXiv, 2018
The conventional nonparametric tests in survival analysis, such as the log-rank test, assess the null hypothesis that the hazards are equal at all times. However, hazards are hard to interpret causally, and other null hypotheses are more relevant in many scenarios with survival outcomes.
arxiv  

Adjuvant Sunitinib in High-Risk Renal-Cell Carcinoma after Nephrectomy.

New England Journal of Medicine, 2016
BACKGROUND Sunitinib, a vascular endothelial growth factor pathway inhibitor, is an effective treatment for metastatic renal-cell carcinoma. We sought to determine the efficacy and safety of sunitinib in patients with locoregional renal-cell carcinoma at
A. Ravaud, R. Motzer, H. Pandha, D. George, A. Pantuck, Anup Patel, Yen‐Hwa Chang, B. Escudier, F. Donskov, A. Magheli, G. Cartenì, B. Laguerre, P. Tomczak, J. Breza, P. Gerletti, M. Lechuga, Xun Lin, J. Martini, K. Ramaswamy, M. Casey, M. Staehler, J. Patard   +21 more
semanticscholar   +1 more source

Stereotactic radiosurgery for multiple small brain metastases using gamma knife versus single‐isocenter VMAT: Normal brain dose based on lesion number and size

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose The study evaluates rapid linear accelerator (Linac) single isocenter stereotactic radiosurgery (SRS) with Hyperarc for large target numbers. We compared to Gamma Knife (GK), which suffers from long treatment times and investigated causes of differences. Methods Linac SRS and GK treatment plans for patients receiving 18 Gy to the gross
Abram Abdou, Timoteo Almeida, Elizabeth Bossart, Irene Monterroso, Eric A. Mellon   +4 more
wiley   +1 more source

Vaccination with nanoparticles combined with micro-adjuvants protects against cancer

Journal for ImmunoTherapy of Cancer, 2019
Background Induction of strong T cell responses, in particular cytotoxic T cells, is a key for the generation of efficacious therapeutic cancer vaccines which yet, remains a major challenge for the vaccine developing world. Here we demonstrate that it is
Mona O. Mohsen, Matthew D. Heath, Gustavo Cabral-Miranda, Cyrill Lipp, Andris Zeltins, Marcos Sande, Jens V. Stein, Carsten Riether, Elisa Roesti, Lisha Zha, Paul Engeroff, Aadil El-Turabi, Thomas M. Kundig, Monique Vogel, Murray A. Skinner, Daniel E. Speiser, Alexander Knuth, Matthias F. Kramer, Martin F. Bachmann   +18 more
doaj   +1 more source

Adjuvant chemotherapy [PDF]

Cancer, 1978
In this brief presentation, an attempt was made to illustrate why it is not possible to carry over chemotherapeutic trial results from one animal cancer to another or one human cancer to another without corrections for differences in (a) staging, (b) dose response, and (c) tumor regrowth rates.
openaire   +2 more sources

Dosimetric effect of silicone‐based gel on skin surface during volumetric modulated arc therapy for breast cancer

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose This study aims to quantify and compare the dosimetric effects of varying thicknesses of StrataXRT, a silicone‐based gel, and other topical agents on the skin surface during volumetric modulated arc therapy (VMAT) for breast cancer.
Tenyoh Suzuki, Shingo Ohira, Mami Ogita, Takeshi Ohta, Yuki Nozawa, Masanari Minamitani, Takuya Hayashi, Shigeki Saegusa, Toshikazu Imae, Tsuyoshi Ueyama, Atsuto Katano, Hideomi Yamashita, Weishan Chang, Keiichi Nakagawa   +13 more
wiley   +1 more source

Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity

Frontiers in Nutrition, 2019
Vitamins are micronutrients that have physiological effects on various biological responses, including host immunity. Therefore, vitamin deficiency leads to increased risk of developing infectious, allergic, and inflammatory diseases.
Ken Yoshii, Ken Yoshii, Koji Hosomi, Kento Sawane, Kento Sawane, Kento Sawane, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa   +11 more
doaj   +1 more source

Surface dose analysis and dosimetric comparison of Halcyon versus Truebeam in breast cancer radiotherapy: An OSL dosimetry study

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Breast cancer is a neoplastic disease with high prevalence among women. Radiotherapy is one of the principal treatment modalities for this disease, but it poses significant challenges. This study aimed to compare and evaluate the technical and dosimetric performance of conventional C‐arm linac systems and a new design, Halcyon, in the ...
Mustafa Çağlar, Kudret Akçay, Esra Serin, Dursun Eşitmez, Mehmet Sıddık Cebe, Navid Kheradmand, Ömer Yazıcı, Dilek Ünal, Evrim Metcalfe   +8 more
wiley   +1 more source

Bayesian Nonparametric Cost-Effectiveness Analyses: Causal Estimation and Adaptive Subgroup Discovery [PDF]

arXiv, 2020
Cost-effectiveness analyses (CEAs) are at the center of health economic decision making. While these analyses help policy analysts and economists determine coverage, inform policy, and guide resource allocation, they are statistically challenging for several reasons. Cost and effectiveness are correlated and follow complex joint distributions which are
arxiv