Results 311 to 320 of about 809,966 (374)

NETs‐CD44‐IL‐17A Feedback Loop Drives Th17‐Mediated Inflammation in Behçet's Uveitis

Advanced Science, EarlyView.
In experimental autoimmune uveitis (EAU), neutrophils interact with T helper 17 (Th17) cells through neutrophil extracellular traps (NETs) to exert a pro‐inflammatory effect. In vitro and in vivo experiments identify that NETs promote IL‐17A secretion in Th17 cells via CD44, and increasing IL‐17A further induces more NETs formation.
Yi Wu, Kang Ning, Zhaohao Huang, Binyao Chen, Junjie Chen, Yingying Wen, Jian Bu, Han Hong, Qiaorong Chen, Zhuoqi Zhang, Renbing Jia, Wenru Su   +11 more
wiley   +1 more source

Neck Dissection and Survival Among Head and Neck Cancer Patients Undergoing Adjuvant Immunotherapy. [PDF]

Laryngoscope Investig Otolaryngol
Patel AM, Haleem A, Cowan PT, Roden DF.
europepmc   +1 more source

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

Advanced Science, EarlyView.
By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan, Xing He, Su Wu, Na Xiong, Xinyu Hou, Heting Wang, Diane Somlo, Martin Spiess, Haiyang Wang, Jifeng Yang, Chunliang Li, Shasha Li, Wenbin Ma, Yanming Chen, Jun Cui, Ling Qi, Guojun Shi   +16 more
wiley   +1 more source

Contemporary Patterns of Care for Low-Grade Glioma in Australia and New Zealand. [PDF]

Curr Oncol
Maddula M, McNamee N, Gan HK, Satgunaseelan L, Koh ES, Han CH, Thavaneswaran S.   +6 more
europepmc   +1 more source

Loss of Golga7 Suppresses Oncogenic Nras‐Driven Leukemogenesis without Detectable Toxicity in Adult Mice

Advanced Science, EarlyView.
NRAS mutations are widespread in hematologic malignancies. Our study shows that GOLGA7 serves as a safe and effective therapeutic target for NRAS‐driven leukemia. Loss of Golga7 in adult mice effectively suppresses NrasG12D‐driven myeloproliferative neoplasm by disrupting its PM localization and impairing subsequent MAPK signaling, without affecting ...
Bo Jiao, Lei Yan, Rui Zhang, Wei Huang, Xinru Wang, Chenxuan Liu, Peihong Wang, Pengfei Xu, Jinzeng Wang, Zhou Fang, Donghe Li, Zhizhou Xia, Jiaoyang Li, Shiyu Ji, Qianqian Zhang, Min Wu, Shengyue Wang, Ping Liu, Ruibao Ren   +18 more
wiley   +1 more source

Calibration of transition probabilities to model survival of adjuvant trastuzumab for early breast cancer in Indonesia. [PDF]

Int J Technol Assess Health Care
Rahadi A, Mahardya RTK, Listiani P, Herlinawaty E, Nugraha RR, Budiman DR, Suharlim C.   +6 more
europepmc   +1 more source

High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection

Advanced Science, EarlyView.
Mapping global epidemiological data to macronutrient supply reveals high carbohydrate, in contrast to high fat supply, associates with increased multiple sclerosis (MS) prevalence and incidence. This is confirmed in a mouse MS model, experimental autoimmune encephalomyelitis (EAE), using isocaloric diets: a high carbohydrate diet aggravates, a high ...
Duan Ni, Jian Tan, Julen Reyes, Alistair M Senior, Caitlin Andrews, Jemma Taitz, Camille Potier‐Villette, Claire Wishart, Alanna Spiteri, Laura Piccio, Nicholas Jonathan Cole King, Romain Barrès, David Raubenheimer, Stephen James Simpson, Ralph Nanan, Laurence Macia   +15 more
wiley   +1 more source

Adjuvant Chemotherapy for High-Risk Stage II Colon Cancer: A Population-Based Study. [PDF]

J Gastrointest Cancer
Butare A, Sutton T, Kantzler E, Kennedy KN, Tumin D, Honaker MD.   +5 more
europepmc   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

A population‑based propensity score matching analysis of neoadjuvant compared to adjuvant chemotherapy in luminal breast cancer. [PDF]

Sci Rep
Zheng C, Zheng D, Zhang Y, Lin R, Zheng Z.   +4 more
europepmc   +1 more source