Results 61 to 70 of about 658,149 (311)

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source

ENDOSCOPIC THIRD VENTRICULOSTOMY IN THE TREATMENT OF NORMOTENSIVE HYDROCEPHALUS. A CLINICAL CASE

Клінічна та профілактична медицина
Introduction. Normotensive hydrocephalus is an abnormal accumulation of cerebrospinal fluid in the ventricles of the brain. This causes an increase in the enlargement of the ventricles and an increase in intracranial pressure.
Orest I. Palamar, Andriy P. Huk, Bohdan O. Davydenko, Oleksandr I. Troian, Kateryna M. Molotkovets   +4 more
doaj   +1 more source

Primary Cilia in the Skin: Functions in Immunity and Therapeutic Potential

Frontiers in Cell and Developmental Biology, 2021
The skin is the biggest organ and provides a physical and immunological barrier against pathogen infection. The distribution of primary cilia in the skin of mice has been reported, but which cells in human skin have them has not, and we still know very ...
Manami Toriyama, Manami Toriyama, Manami Toriyama, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii   +5 more
doaj   +1 more source

Adjuvant bevacizumab in patients with melanoma at high risk of recurrence (AVAST-M) : preplanned interim results from a multicentre, open-label, randomised controlled phase 3 study [PDF]

, 2014
Background: Bevacizumab, a monoclonal antibody that targets VEGF, has shown restricted activity in patients with advanced melanoma. We aimed to assess the role of bevacizumab as adjuvant treatment for patients with resected melanoma at high risk of ...
N. Davidson (7671467), J. P. Nobes (7671491), P. Lorigan (7671500), Harries, M., C. G. Kelly (7671473), A. Marshall (7671452), M. R. Middleton (7671458), Dunn, Janet A, Houston, Stephen J, Board, Ruth E., Steve Nicholson (7671470), Lorigan, P., Waterston, A.M., Nobes, Jenny P., Gore, M.E., Kelly, Charles G, Danson, S., Nathan, Paul D, Nathan, Paul D., Kumar, S., Middleton, Mark R., Davidson, Neville, Marples, M., Nobes, Jenny P, Waterston, Ashita M, Young, G., Dunn, J., Nathan, P.D., Lorigan, Paul; id_orcid, Houston, S., Danson, Sarah J, M. Gore (7671464), Davidson, D., Board, R.E., M. Marples (7671476), Dunn, Janet A., Nobes, J.P., Marshall, E., Corrie, P., S. J. Danson (7671479), Marshall, A., Middleton, Mark R, Board, Ruth E, Middleton, M.R., Marshall, Ernest, Gore, Martin, Marples, Maria, Corrie, Pippa G, P. D. Nathan (7671461), G Young (7671497), E. Marshall (7241588), Houston, Stephen J., Young, Gemma, Nicholson, Steve, A. M. Waterston (7671488), Kelly, Charles G., P. G. Corrie (7671449), S. J. Houston (7671482), Kelly, C.G., Corrie, Pippa G., M. Harries (7671494), Marshall, Andrea, Kumar, Satish, S. Kumar (746162), Nicholson, S., Waterston, Ashita M., R. E. Board (7671485), Harries, Mark, Danson, Sarah J., Marshall, A. (Andrea)‏, Lorigan, Paul, J. A. Dunn (7671455)   +71 more
core   +1 more source

Global Efforts to Reduce Paediatric Cancer Care Disparities in Radiotherapy: A Decade Change

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We present an update on the status, needs and challenges faced by paediatric imaging and radiotherapy (RT) programmes globally after a previous survey conducted by the International Atomic Energy Agency (IAEA) 10 years prior. Methods We developed and distributed a 121‐question survey to radiation oncologists, medical physicists and ...
Raymond B. Mailhot Vega, Daniel J. Indelicato, Jeanette Parkes, Natia Esiashvili, Josué Hernández Benítez, Miriam Mikhail‐Lette, Olivera Cirajc Bjelac, Daniel Berger, Eva Ciurana, Yavuz Anacak, Lisbeth Cordero‐Mendez   +10 more
wiley   +1 more source

Mead acid inhibits retinol-induced irritant contact dermatitis via peroxisome proliferator-activated receptor alpha

Frontiers in Molecular Biosciences, 2023
Retinol is widely used in topical skincare products to ameliorate skin aging and treat acne and wrinkles; however, retinol and its derivatives occasionally have adverse side effects, including the induction of irritant contact dermatitis.
Azusa Saika, Prabha Tiwari, Prabha Tiwari, Takahiro Nagatake, Takahiro Nagatake, Eri Node, Koji Hosomi, Tetsuya Honda, Kenji Kabashima, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa   +14 more
doaj   +1 more source

Metastatic breast cancers have reduced immune cell recruitment but harbor increased macrophages relative to their matched primary tumors

Journal for ImmunoTherapy of Cancer, 2019
The interplay between the immune system and tumor progression is well recognized. However, current human breast cancer immunophenotyping studies are mostly focused on primary tumors with metastatic breast cancer lesions remaining largely understudied. To
Li Zhu, Jessica L. Narloch, Sayali Onkar, Marion Joy, Gloria Broadwater, Catherine Luedke, Allison Hall, Rim Kim, Katherine Pogue-Geile, Sarah Sammons, Naema Nayyar, Ugonma Chukwueke, Priscilla K. Brastianos, Carey K. Anders, Adam C. Soloff, Dario A. A. Vignali, George C. Tseng, Leisha A. Emens, Peter C. Lucas, Kimberly L. Blackwell, Steffi Oesterreich, Adrian V. Lee   +21 more
doaj   +1 more source

Enzymatically synthesized exopolysaccharide of a probiotic strain Leuconostoc mesenteroides NTM048 shows adjuvant activity to promote IgA antibody responses

Gut Microbes, 2021
Leuconostoc mesenteroides strain NTM048 produces an exopolysaccharide (EPS; glucose polymers 94% and fructose polymers 6%) with adjuvanticity for mucosal vaccination.
Chiaki Matsuzaki, Yukari Nakashima, Ikuto Endo, Yusuke Tomabechi, Yasuki Higashimura, Saki Itonori, Koji Hosomi, Jun Kunisawa, Kenji Yamamoto, Keiko Hisa   +9 more
doaj   +1 more source

Chemically Synthesized Alcaligenes Lipid A as an Adjuvant to Augment Immune Responses to Haemophilus Influenzae Type B Conjugate Vaccine

Frontiers in Pharmacology, 2021
We previously identified Alcaligenes spp. as a commensal bacterium that resides in lymphoid tissues, including Peyer’s patches. We found that Alcaligenes-derived lipopolysaccharide acted as a weak agonist of Toll-like receptor four due to the unique ...
Zilai Liu, Zilai Liu, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Ken Yoshii, Xiao Sun, Xiao Sun, Huangwenxian Lan, Huangwenxian Lan, Yunru Wang, Yunru Wang, Haruki Yamaura, Davie Kenneth, Azusa Saika, Azusa Saika, Takahiro Nagatake, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa   +30 more
doaj   +1 more source

Data adjuvant therapy dose schedules

, 2020
Data file of simulated dose schedules that prevent the recurrence of colon cancer by apoptotic adjuvant therapy. Includes numerical data in columns for Interval, Duration, Treatment, and 50-year dose sum, ranked by 50-year dose sum.

core   +1 more source