Results 41 to 50 of about 658,149 (311)

Chemically Synthesized Alcaligenes Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of Streptococcus pneumoniae-Specific IgA and Th17 Mediated Protective Immunity

Microorganisms, 2020
Effective and safe vaccine adjuvants are needed to appropriately augment mucosal vaccine effects. Our previous study demonstrated that lipopolysaccharide (LPS) from Peyer’s patch resident Alcaligenes stimulated dendritic cells to promote the production ...
Ken Yoshii, Koji Hosomi, Atsushi Shimoyama, Yunru Wang, Haruki Yamaura, Takahiro Nagatake, Hidehiko Suzuki, Huangwenxian Lan, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa   +10 more
doaj   +1 more source

Clinical feasibility of (neo)adjuvant taxane-based chemotherapy in older patients : analysis of >4,500 patients from four German randomized breast cancer trials [PDF]

, 2008
Introduction: Despite the fact that people older than 65 years of age have the highest incidence of developing breast cancer, these patients are excluded from clinical trials in most cases.
Kümmel, Sherko, Sibylle Loibl, Gunter von Minckwitz, Kuemmel, Sherko, Valentina Nekljudova, Marion Kiechle, Elling, Dirk, Holm Eggemann, Harald Sommer, Janni, Wolfgang, Sommer, Harald, Wolfgang Janni, Loibl, Sibylle, Nadia Harbeck, Manfred Kaufmann, Harbeck, Nadia, Nekljudova, Valentina, Minckwitz, Gunter von, Sherko Kümmel, Kiechle, Marion, Kaufmann, Manfred, Eggemann, Holm, Dirk Elling   +22 more
core   +2 more sources

Shaping Modern Vaccines: Adjuvant Systems Using MicroCrystalline Tyrosine (MCT®)

Frontiers in Immunology, 2020
The concept of adjuvants or adjuvant systems, used in vaccines, exploit evolutionary relationships associated with how the immune system may initially respond to a foreign antigen or pathogen, thus mimicking natural exposure.
Matthew D. Heath, Matthew D. Heath, Mona O. Mohsen, Mona O. Mohsen, Pieter-Jan de Kam, Thalia L. Carreno Velazquez, Simon J. Hewings, Simon J. Hewings, Matthias F. Kramer, Matthias F. Kramer, Thomas M. Kündig, Martin F. Bachmann, Martin F. Bachmann, Murray A. Skinner, Murray A. Skinner   +14 more
doaj   +1 more source

Endotoxin-Free Stx2B-C-CPE Vaccine and Its Optimized Adjuvant Regimen for Preventing Food Poisoning

Frontiers in Bioscience-Landmark, 2023
Background: Clostridium perfringens and Shiga toxin (Stx)-producing Escherichia coli (STEC) are common causes of food poisoning. We previously demonstrated the efficacy of Stx2B-C-CPE, a fusion protein of the C-terminal region of C.
Koji Hosomi, Atsushi Shimoyama, Atsushi Hinenoya, Noritoshi Hatanaka, Takafumi Noguchi, Hirotaka Ebina, Yoko Tojima, Mari Furuta, Masuo Kondoh, Hiroshi Kiyono, Shinji Yamasaki, Koichi Fukase, Jun Kunisawa   +12 more
doaj   +1 more source

Alum Activates the Bovine NLRP3 Inflammasome

Frontiers in Immunology, 2017
There has been a move away from vaccines composed of whole or inactivated antigens toward subunit-based vaccines, which although safe, provide less immunological protection.
Ciaran Harte, Ciaran Harte, Aoife L. Gorman, S. McCluskey, Michael Carty, Andrew G. Bowie, C. J. Scott, Kieran G. Meade, Ed C. Lavelle   +8 more
doaj   +1 more source

Assessment of Fcγ receptor-dependent binding of influenza hemagglutinin vaccine-induced antibodies in a non-human primate model

iScience, 2022
Summary: Several cross-protective antibodies that recognize a broad range of influenza A virus (IAV) strains are known to have functions in virus elimination such as Fcγ receptor (FcγR)-effector function and neutralizing activity against the head region.
Yuji Masuta, Shokichi Takahama, Takuto Nogimori, Saya Moriyama, Yoshimasa Takahashi, Takuya Yamamoto   +5 more
doaj   +1 more source

Statins as adjuvants [PDF]

Nature Reviews Immunology, 2018
Besides cholesterol lowering, statins boost antigen presentation and adaptive immune responses, suggesting new uses as adjuvants for cancer immunotherapy.
openaire   +2 more sources

Effect of Preexisting Immunity to Tetanus Toxoid on the Efficacy of Tetanus Toxoid-Conjugated Heroin Vaccine in Mice

Vaccines, 2021
Opioid use disorder (OUD) is a serious health problem that has dramatically increased over the last decade. Although current therapies for the management of OUD can be effective, they have limitations.
Essie Komla, Oscar B. Torres, Rashmi Jalah, Agnieszka Sulima, Zoltan Beck, Carl R. Alving, Arthur E. Jacobson, Kenner C. Rice, Gary R. Matyas   +8 more
doaj   +1 more source

Human Primary Macrophages Derived In Vitro from Circulating Monocytes Comprise Adherent and Non-Adherent Subsets with Differential Expression of Siglec-1 and CD4 and Permissiveness to HIV-1 Infection

Frontiers in Immunology, 2017
Macrophages are a major target for human immunodeficiency virus type 1 (HIV-1) infection. However, macrophages are largely heterogeneous and may exhibit differences in permissiveness to HIV-1 infection.
Ousman Jobe, Ousman Jobe, Jiae Kim, Jiae Kim, Eric Tycksen, Sayali Onkar, Sayali Onkar, Nelson L. Michael, Carl R. Alving, Mangala Rao   +9 more
doaj   +1 more source

Correction: Zika Virus-Derived E-DIII Protein Displayed on Immunologically Optimized VLPs Induces Neutralizing Antibodies without Causing Enhancement of Dengue Virus Infection. Vaccines 2019, 7, 72

Vaccines, 2020
The authors wish to make the following correction to their paper [...]
Gustavo Cabral-Miranda, Stephanie M. Lim, Mona O. Mohsen, Ilya V. Pobelov, Elisa S. Roesti, Matthew D. Heath, Murray A. Skinner, Matthias F. Kramer, Byron E.E Martina, Martin F. Bachmann   +9 more
doaj   +1 more source