Results 21 to 30 of about 492,135 (265)

SARS-CoV-2 spike-ferritin-nanoparticle adjuvanted with ALFQ induces long-lived plasma cells and cross-neutralizing antibodies

npj Vaccines, 2023
This study demonstrates the impact of adjuvant on the development of T follicular helper (Tfh) and B cells, and their influence on antibody responses in mice vaccinated with SARS-CoV-2-spike-ferritin-nanoparticle (SpFN) adjuvanted with either Army ...
Shikha Shrivastava, Joshua M. Carmen, Zhongyan Lu, Shraddha Basu, Rajeshwer S. Sankhala, Wei-Hung Chen, Phuong Nguyen, William C. Chang, Jocelyn King, Courtney Corbitt, Sandra Mayer, Jessica S. Bolton, Alexander Anderson, Isabella Swafford, Guillermo D. Terriquez, Hung V. Trinh, Jiae Kim, Ousman Jobe, Dominic Paquin-Proulx, Gary, R. Matyas, Gregory D. Gromowski, Jeffrey R. Currier, Elke Bergmann-Leitner, Kayvon Modjarrad, Nelson L. Michael, M. Gordon Joyce, Allison M. W. Malloy, Mangala Rao   +27 more
doaj   +1 more source

S-540956, a CpG Oligonucleotide Annealed to a Complementary Strand With an Amphiphilic Chain Unit, Acts as a Potent Cancer Vaccine Adjuvant by Targeting Draining Lymph Nodes

Frontiers in Immunology, 2021
Robust induction of cancer-antigen-specific CD8+ T cells is essential for the success of cancer peptide vaccines, which are composed of a peptide derived from a cancer-specific antigen and an immune-potentiating adjuvant, such as a Toll-like receptor ...
Takayuki Nakagawa, Tetsuya Tanino, Motoyasu Onishi, Soichi Tofukuji, Takayuki Kanazawa, Yukichi Ishioka, Takeshi Itoh, Akira Kugimiya, Kazufumi Katayama, Takuya Yamamoto, Morio Nagira, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii   +13 more
doaj   +1 more source

Functional changes in cytotoxic CD8+ T-cell cross-reactivity against the SARS-CoV-2 Omicron variant after mRNA vaccination

Frontiers in Immunology, 2023
Understanding the T-cell responses involved in inhibiting COVID-19 severity is crucial for developing new therapeutic and vaccine strategies. Here, we characterized SARS-CoV-2 spike-specific CD8+ T cells in vaccinees longitudinally.
Takuto Nogimori, Takuto Nogimori, Koichiro Suzuki, Yuji Masuta, Yuji Masuta, Ayaka Washizaki, Ayaka Washizaki, Mika Yagoto, Mami Ikeda, Yuki Katayama, Hidenori Kanda, Minoru Takada, Shohei Minami, Takeshi Kobayashi, Shokichi Takahama, Shokichi Takahama, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Takuya Yamamoto, Takuya Yamamoto, Takuya Yamamoto, Takuya Yamamoto, Takuya Yamamoto   +24 more
doaj   +1 more source

Instillation of Particulate Suspensions to the Lungs

Bio-Protocol, 2017
Inhaled fine particulates are thought to cause chronic pulmonary inflammation through the deposition of particulates into the lungs. To investigate the effect of fine particulates on the lungs, instillation of suspension of particulates into the lungs is
Etsushi Kuroda, Yasuo Morimoto, Ken Ishii   +2 more
doaj   +1 more source

Hypofractionated radiation therapy comparing a standard radiotherapy schedule (over 3 weeks) with a novel 1-week schedule in adjuvant breast cancer: an open-label randomized controlled study (HYPORT-Adjuvant)—study protocol for a multicentre, randomized phase III trial

Trials, 2020
Background Hypofractionated radiotherapy is the current standard for adjuvant radiotherapy across many centres. Further hypofractionation may be possible but remains to be investigated in non-Caucasian populations with more advanced disease, with a ...
Sanjoy Chatterjee, Santam Chakraborty, HYPORT Adjuvant Author Group   +2 more
doaj   +1 more source

Adjuvant system AS01: helping to overcome the challenges of modern vaccines

Expert Review of Vaccines, 2017
Introduction: Adjuvants are used to improve vaccine immunogenicity and efficacy by enhancing antigen presentation to antigen-specific immune cells with the aim to confer long-term protection against targeted pathogens.
Arnaud M. Didierlaurent, Béatrice Laupèze, Alberta Di Pasquale, Nadia Hergli, Catherine Collignon, Nathalie Garçon   +5 more
doaj   +1 more source

Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota

Nature Communications, 2022
Here, the authors inversely associate Blautia wexlerae with obesity and type 2 diabetes mellitus in humans and further show that administration of B. wexlerae to mice decrease both high-fat diet–induced obesity and diabetes via modulating gut microbial ...
Koji Hosomi, Mayu Saito, Jonguk Park, Haruka Murakami, Naoko Shibata, Masahiro Ando, Takahiro Nagatake, Kana Konishi, Harumi Ohno, Kumpei Tanisawa, Attayeb Mohsen, Yi-An Chen, Hitoshi Kawashima, Yayoi Natsume-Kitatani, Yoshimasa Oka, Hidenori Shimizu, Mari Furuta, Yoko Tojima, Kento Sawane, Azusa Saika, Saki Kondo, Yasunori Yonejima, Haruko Takeyama, Akira Matsutani, Kenji Mizuguchi, Motohiko Miyachi, Jun Kunisawa   +26 more
doaj   +1 more source

Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor

Frontiers in Immunology, 2019
Extracellular host-derived DNA, as one of damage associated molecular patterns (DAMPs), is associated with allergic type 2 immune responses. Immune recognition of such DNA generates the second messenger cyclic GMP-AMP (cGAMP) and induces type-2 immune ...
Koji Ozasa, Koji Ozasa, Burcu Temizoz, Burcu Temizoz, Burcu Temizoz, Burcu Temizoz, Takato Kusakabe, Takato Kusakabe, Takato Kusakabe, Shingo Kobari, Shingo Kobari, Masatoshi Momota, Masatoshi Momota, Cevayir Coban, Cevayir Coban, Cevayir Coban, Shuichi Ito, Kouji Kobiyama, Kouji Kobiyama, Kouji Kobiyama, Kouji Kobiyama, Etsushi Kuroda, Etsushi Kuroda, Etsushi Kuroda, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii   +28 more
doaj   +1 more source

Adjuvant Activity of Synthetic Lipid A of Alcaligenes, a Gut-Associated Lymphoid Tissue-Resident Commensal Bacterium, to Augment Antigen-Specific IgG and Th17 Responses in Systemic Vaccine

Vaccines, 2020
Alcaligenes spp. are identified as commensal bacteria and have been found to inhabit Peyer’s patches in the gut. We previously reported that Alcaligenes-derived lipopolysaccharides (LPS) exerted adjuvant activity in systemic vaccination, without ...
Yunru Wang, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Haruki Yamaura, Takahiro Nagatake, Tomomi Nishino, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa   +9 more
doaj   +1 more source

DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination

Frontiers in Immunology, 2018
Recently, it was reported that 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD), a common pharmaceutical additive, can act as a vaccine adjuvant to enhance protective type-2 immunogenicity to co-administered seasonal influenza split vaccine by inducing host ...
Tomoya Hayashi, Tomoya Hayashi, Masatoshi Momota, Masatoshi Momota, Etsushi Kuroda, Etsushi Kuroda, Takato Kusakabe, Takato Kusakabe, Shingo Kobari, Kotaro Makisaka, Yoshitaka Ohno, Yoshitaka Ohno, Yusuke Suzuki, Fumika Nakagawa, Michelle S. J. Lee, Cevayir Coban, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Ken J. Ishii, Ken J. Ishii, Hidetoshi Arima, Hidetoshi Arima   +22 more
doaj   +1 more source