Results 31 to 40 of about 678,613 (312)

Chemically Synthesized Alcaligenes Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of Streptococcus pneumoniae-Specific IgA and Th17 Mediated Protective Immunity

Microorganisms, 2020
Effective and safe vaccine adjuvants are needed to appropriately augment mucosal vaccine effects. Our previous study demonstrated that lipopolysaccharide (LPS) from Peyer’s patch resident Alcaligenes stimulated dendritic cells to promote the production ...
Ken Yoshii, Koji Hosomi, Atsushi Shimoyama, Yunru Wang, Haruki Yamaura, Takahiro Nagatake, Hidehiko Suzuki, Huangwenxian Lan, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa   +10 more
doaj   +1 more source

Adjuvant-Protein Conjugate Vaccine with Built-In TLR7 Agonist on S1 Induces Potent Immunity against SARS-CoV‑2 and Variants of Concern

, 2022
With the global pandemic of the new coronavirus disease (COVID-19), a safe, effective, and affordable mass-produced vaccine remains the current focus of research.
Ru-Yan Zhang (6443417), Shi-Hao Zhou (11994123), Xu-Guang Yin (3332247), Chen-Bin He (12935216), Jian Wang (5901), Guang-Fu Yang (364659), Jun Guo (85069), Yu Wen (303123), Ran-Ran Feng (12935219)   +8 more
core   +1 more source

Neoadjuvant–Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma [PDF]

, 2023
BACKGROUND: Whether pembrolizumab given both before surgery (neoadjuvant therapy) and after surgery (adjuvant therapy), as compared with pembrolizumab given as adjuvant therapy alone, would increase event-free survival among patients with resectable ...
Wu, Richard C, Yost, Kathleen J, Korde, Larissa, Ribas, Antoni, Devoe, Craig E, Hyngstrom, John R, In, Gino K, Moon, James, Kendra, Kari L, Chandra, Sunandana, Chow, Warren A, Grossmann, Kenneth F, Sondak, Vernon K, Doolittle, Gary C, Hegde, Aparna, Gibney, Geoffrey T, Kokot, Niels, Chmielowski, Bartosz, Mangla, Ankit, Chen, Yuanbin, Poklepovic, Andrew S, Warneke, James A, Hu-Lieskovan, Siwen, Margolin, Kim A, Reese, Amy M, Wright, G Paul, Fecher, Leslie A, Atkins, Michael B, Crompton, Joseph G, Yasar, Demet G, Kirkwood, John M, Shaheen, Montaser, Eisenstein, Jennifer L, Truong, Thach-Giao, Prieto, Victor G, Phan, Giao Q, Patel, Sapna P, Sosman, Jeffrey A, Dietrich, Eliana, Powers, Benjamin C, Onitilo, Adedayo A, Lao, Christopher D, Khalil, Maya, Lowe, Michael C, Deutsch, Gary B, Floyd, Justin D, Ikeguchi, Alexandra, Buchbinder, Elizabeth I, Sharon, Elad, Najera, Jose E, Othus, Megan, Ross, Merrick I, Hsueh, Eddy, Adedayo A. Onitilo, Justin D. Floyd, Thach-Giao Truong, Andrew S. Poklepovic, Kari L. Kendra, Bartosz Chmielowski, Craig E. Devoe, Jeffrey A. Sosman, Warren A. Chow, Eddy Hsueh, Michael C. Lowe, Megan Othus, Yuanbin Chen, Alexandra Ikeguchi, Geoffrey T. Gibney, Vernon K. Sondak, John R. Hyngstrom, Gary C. Doolittle, Jose E. Najera, Kim A. Margolin, Leslie A. Fecher, G. Paul Wright, Christopher D. Lao, Antoni Ribas, Kenneth F. Grossmann, Maya Khalil, James Moon, James A. Warneke, Eliana Dietrich, Sapna P. Patel, Elad Sharon, Gary B. Deutsch, Niels Kokot, Michael B. Atkins, Larissa Korde, Merrick I. Ross, Sunandana Chandra, Demet G. Yasar, Aparna Hegde, Montaser Shaheen, Elizabeth I. Buchbinder, John M. Kirkwood, Victor G. Prieto, Ankit Mangla, Amy M. Reese, Giao Q. Phan, Siwen Hu-Lieskovan, Gino K. In, Jennifer L. Eisenstein, Richard C. Wu, Kathleen J. Yost, Benjamin C. Powers, Joseph G. Crompton   +105 more
core   +1 more source

Endotoxin-Free Stx2B-C-CPE Vaccine and Its Optimized Adjuvant Regimen for Preventing Food Poisoning

Frontiers in Bioscience-Landmark, 2023
Background: Clostridium perfringens and Shiga toxin (Stx)-producing Escherichia coli (STEC) are common causes of food poisoning. We previously demonstrated the efficacy of Stx2B-C-CPE, a fusion protein of the C-terminal region of C.
Koji Hosomi, Atsushi Shimoyama, Atsushi Hinenoya, Noritoshi Hatanaka, Takafumi Noguchi, Hirotaka Ebina, Yoko Tojima, Mari Furuta, Masuo Kondoh, Hiroshi Kiyono, Shinji Yamasaki, Koichi Fukase, Jun Kunisawa   +12 more
doaj   +1 more source

Data adjuvant therapy dose schedules

, 2020
Data file of simulated dose schedules that prevent the recurrence of colon cancer by apoptotic adjuvant therapy. Includes numerical data in columns for Interval, Duration, Treatment, and 50-year dose sum, ranked by 50-year dose sum.

core   +1 more source

Clinical feasibility of (neo)adjuvant taxane-based chemotherapy in older patients : analysis of >4,500 patients from four German randomized breast cancer trials [PDF]

, 2008
Introduction: Despite the fact that people older than 65 years of age have the highest incidence of developing breast cancer, these patients are excluded from clinical trials in most cases.
Kümmel, Sherko, Sibylle Loibl, Gunter von Minckwitz, Kuemmel, Sherko, Valentina Nekljudova, Marion Kiechle, Elling, Dirk, Holm Eggemann, Harald Sommer, Janni, Wolfgang, Sommer, Harald, Wolfgang Janni, Loibl, Sibylle, Nadia Harbeck, Manfred Kaufmann, Harbeck, Nadia, Nekljudova, Valentina, Minckwitz, Gunter von, Sherko Kümmel, Kiechle, Marion, Kaufmann, Manfred, Eggemann, Holm, Dirk Elling, Loibl, S;von Minckwitz, G;Harbeck, N;Janni, W;Elling, D;Kaufmann, M;Eggemann, H;Nekljudova, V;Sommer, H;Kiechle, M;Kümmel, S   +23 more
core   +2 more sources

Alum Activates the Bovine NLRP3 Inflammasome

Frontiers in Immunology, 2017
There has been a move away from vaccines composed of whole or inactivated antigens toward subunit-based vaccines, which although safe, provide less immunological protection.
Ciaran Harte, Ciaran Harte, Aoife L. Gorman, S. McCluskey, Michael Carty, Andrew G. Bowie, C. J. Scott, Kieran G. Meade, Ed C. Lavelle   +8 more
doaj   +1 more source

Assessment of Fcγ receptor-dependent binding of influenza hemagglutinin vaccine-induced antibodies in a non-human primate model

iScience, 2022
Summary: Several cross-protective antibodies that recognize a broad range of influenza A virus (IAV) strains are known to have functions in virus elimination such as Fcγ receptor (FcγR)-effector function and neutralizing activity against the head region.
Yuji Masuta, Shokichi Takahama, Takuto Nogimori, Saya Moriyama, Yoshimasa Takahashi, Takuya Yamamoto   +5 more
doaj   +1 more source

The Role of Tomatine Adjuvant in Antigen Delivery for Cross-Presentation

, 2017
The aim of this study was to investigate the use of tomatine adjuvant to deliver soluble antigen for cross-presentation by bone marrow-derived dendritic cells (BMDCs).
Hsu, Paul Y. -J.;Wu, Ching-An;Shen, Shan-Shan;Yang, Ya-Wun, 楊雅雯   +1 more
core   +1 more source

Statins as adjuvants [PDF]

Nature Reviews Immunology, 2018
Besides cholesterol lowering, statins boost antigen presentation and adaptive immune responses, suggesting new uses as adjuvants for cancer immunotherapy.
openaire   +2 more sources