Results 111 to 120 of about 1,201,269 (362)

A Novel 3D High‐Throughput Phenotypic Drug Screening Pipeline to Identify Drugs with Repurposing Potential for the Treatment of Ovarian Cancer

Advanced Healthcare Materials, EarlyView.
Ovarian cancer's high recurrence and therapy resistance demand new strategies. A high‐throughput drug screening pipeline using 3D spheroids, which showed poor concordance with 2D models, identified rapamycin as a promising candidate. In combination with cisplatin, rapamycin demonstrated significant in vitro and in vivo efficacy, highlighting the ...
Nazanin Karimnia, Amy L. Wilson, Brittany R. Doran, Jennie Do, Amelia Matthews, Gwo Y. Ho, Magdalena Plebanski, Thomas W. Jobling, Andrew N. Stephens, Maree Bilandzic   +9 more
wiley   +1 more source

PB2114: TREATMENT RESULTS IN PATIENTS WITH DIFFUSE LARGE B-CELL LYMPHOMA FROM HIGH-RISK GROUP

HemaSphere, 2022
K. Filonenko, I. Kriachok, A. Martynchyk, I. Titorenko, Y. Stepanishyna, O. Aleksyk, K. Ukianchenko, I. Pastushenko, Y. Kushchevyy, O. Novosad, O. Karnabeda, I. Diagil, V. Kozlov   +12 more
doaj   +1 more source

On null hypotheses in survival analysis [PDF]

arXiv, 2018
The conventional nonparametric tests in survival analysis, such as the log-rank test, assess the null hypothesis that the hazards are equal at all times. However, hazards are hard to interpret causally, and other null hypotheses are more relevant in many scenarios with survival outcomes.
arxiv  

Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine.

New England Journal of Medicine, 2007
BACKGROUND Advanced gastric cancer can respond to S-1, an oral fluoropyrimidine. We tested S-1 as adjuvant chemotherapy in patients with curatively resected gastric cancer.
S. Sakuramoto, M. Sasako, Toshiharu Yamaguchi, T. Kinoshitá, M. Fujii, A. Nashimoto, H. Furukawa, T. Nakajima, Y. Ohashi, H. Imamura, M. Higashino, Y. Yamamura, A. Kurita, K. Arai   +13 more
semanticscholar   +1 more source

Injectable 2D‐MoS2‐integrated Bioadhesive Hydrogel as Photothermal‐Derived and Drug‐Delivery Implant for Colorectal Cancer Therapy

Advanced Healthcare Materials, EarlyView.
An injectable, adhesive hydrogel integrating 2D‐MoS2 and 5‐fluorouracil (AlgNB/MoS2/5‐FU) is developed for near‐infrared‐triggered photothermal therapy and localized drug delivery. The adhesive hydrogel demonstrates superior tumor anchoring, efficient photothermal conversion, and synergistic inhibition of colorectal cancer progression, offering a ...
Xiaojun Long, Jiawei Wang, Huijuan Wang, Kepeng Hu, Wei Zhang, Weiming Lin, Chao Fang, Kui Cheng, Zhangfa Song   +8 more
wiley   +1 more source

Association of Adjuvant Chemotherapy With Survival in Patients With Stage II or III Gastric Cancer

JAMA Surgery, 2017
Importance The current staging system of gastric cancer is not adequate for defining a prognosis and predicting the patients most likely to benefit from chemotherapy.
Yuming Jiang, Tuan-jie Li, Xiaoling Liang, Yanfeng Hu, Lei Huang, Z. Liao, Li-ying Zhao, Zhen Han, Shuguang Zhu, Menglan Wang, Yangwei Xu, Xiaolong Qi, Hao Liu, Yang Yang, Jiang Yu, W. Liu, S. Cai, Guoxin Li   +17 more
semanticscholar   +1 more source

Photonic Nanomaterials for Wearable Health Solutions

Advanced Materials, EarlyView.
This review discusses the fundamentals and applications of photonic nanomaterials in wearable health technologies. It covers light‐matter interactions, synthesis, and functionalization strategies, device assembly, and sensing capabilities. Applications include skin patches and contact lenses for diagnostics and therapy. Future perspectives emphasize AI‐
Taewoong Park, Jung Woo Leem, Young L. Kim, Chi Hwan Lee   +3 more
wiley   +1 more source

Efficacy of Adjuvant Chemotherapy in Colon Cancer With Microsatellite Instability: A Large Multicenter AGEO Study.

Journal of the National Cancer Institute, 2016
BACKGROUND Deficient mismatch repair (dMMR) colon cancer (CC) is reportedly resistant to 5-fluorouracil (5FU) adjuvant chemotherapy while preliminary data suggest chemosensitivity to oxaliplatin.
D. Tougeron, G. Mouillet, I. Trouilloud, T. Lecomte, R. Coriat, T. Aparicio, G. Des Guetz, C. Lécaille, P. Artru, Gaelle Sickersen, E. Cauchin, D. Sefrioui, T. Boussaha, A. Ferru, T. Matysiak-Budnik, C. Silvain, L. Karayan‐Tapon, J. Pagès, D. Vernerey, F. Bonnetain, P. Michel, J. Taïeb, A. Zaanan   +22 more
semanticscholar   +1 more source

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

Advanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source

Factors related to patient propensity to receive adjuvant chemotherapy and outcomes in stage III gastric cancer cases after D2 surgery

Asian Journal of Surgery, 2019
Summary: Background: Radical gastrectomy and extended lymph node (D2) dissection followed by adjuvant chemotherapy is the optimal treatment for patients with stage III gastric cancer in Asian population.
Jen-Shi Chen, Chia-Yen Hung, Keng-Hao Liu, Chun-Yi Tsai, Yung-Chia Kuo, Jun-Te Hsu, Wen-Chi Chou   +6 more
doaj