Results 1 to 10 of about 175,213 (250)
Neoplasia, 2011 Low-dose metronomic (LDM) chemotherapy is emerging as an alternative or supplemental dosing strategy to conventional maximum tolerated dose (MTD) chemotherapy. It is characterized primarily, but not exclusively, by antiangiogenic mechanisms of action and
Urban Emmenegger +2 more
exaly +3 more sources
BMJ, 1963 Cyclophosphamide, a recently-developed alkylating agent that may be administered orally, intramuscularly, and intravenously, was given to 135 patients with a wide variety of malignant diseases. Significant benefit was obtained in patients with lymphomas and leukemias as well as malignant melanoma, multiple myeloma, and carcinoma of the ovaries ...
J, SOLOMON +2 more
openaire +4 more sources
Food & Nutrition Research, 2021 Background: Lupus nephritis (LN) is one of the most severe organ that damages the systemic lupus erythematosus (SLE). Cyclophosphamide is one of the main drugs used in the treatment of LN.
Chi Zhang +3 more
doaj +1 more source
Cytochrome P450 Oxidoreductase Influences CYP2B6 Activity in Cyclophosphamide Bioactivation. [PDF]
PLoS ONE, 2015 Cyclophosphamide is commonly used as an important component in conditioning prior to hematopoietic stem cell transplantation, a curative treatment for several hematological diseases.
Ibrahim El-Serafi +4 more
doaj +1 more source
Pharmaceuticals, 2021 Infants and young children represent an important but much understudied childhood cancer patient population. The pharmacokinetics and pharmacogenetics of the widely used anticancer prodrug cyclophosphamide were investigated in children
Shelby Barnett +6 more
doaj +1 more source
A Study on the Alteration of Endoplasmic Reticulum Stress-related Proteins in Cyclophosphamide-induced Damage to Urothelium [PDF]
Pharmaceutical and Biomedical Research, 2023 Background: Cyclophosphamide is widely prescribed as an anti-cancer drug and used as an immunosuppressant. Hemorrhagic cystitis is one of the common complications of cyclophosphamide intake.
Hemalatha R +3 more
doaj
The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats [PDF]
Acta Cirúrgica Brasileira, 2018 Purpose: To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects.
Ercan Yilmaz +5 more
doaj +1 more source
The Egyptian Journal of Histology, 2021 Background: cyclophosphamide is an immunosuppressive agent and anticancer drug in childhood and adult malignant tumors. The compounds that have antioxidant properties might improve the side effect of cyclophosphamide on spermatogenesis.
Hanan Elkerdasy
doaj +1 more source
Cyclophosphamide alters the gene expression profile in patients treated with high doses prior to stem cell transplantation. [PDF]
PLoS ONE, 2014 BACKGROUND: Hematopoietic stem cell transplantation is a curative treatment for several haematological malignancies. However, treatment related morbidity and mortality still is a limiting factor.
Ibrahim El-Serafi +6 more
doaj +1 more source
Journal of Pharmacological Sciences, 2021 The effects of cyclophosphamide on 5-hydroxytryptamine (5-HT) synthesis in the intestinal tissue of rats were investigated. Rats received 120 mg/kg cyclophosphamide intraperitoneally as a single administration, and kaolin and food intake was measured by ...
Akihisa Kamiya +7 more
doaj +1 more source