Results 11 to 20 of about 275,027 (303)

Tumors That Acquire Resistance to Low-Dose Metronomic Cyclophosphamide Retain Sensitivity to Maximum Tolerated Dose Cyclophosphamide

Neoplasia: An International Journal for Oncology Research, 2011
Low-dose metronomic (LDM) chemotherapy is emerging as an alternative or supplemental dosing strategy to conventional maximum tolerated dose (MTD) chemotherapy. It is characterized primarily, but not exclusively, by antiangiogenic mechanisms of action and
Urban Emmenegger, Giulio Francia, Annabelle Chow, Yuval Shaked, Andrew Kouri, Shan Man, Robert S. Kerbel   +6 more
doaj   +1 more source

Post-transplant cyclophosphamide-induced cardiotoxicity: A comprehensive review [PDF]

Journal of Cardiovascular and Thoracic Research
Cyclophosphamide-induced cardiotoxicity, associated with its toxic metabolite acrolein, is a significant concern and unresolved issue, especially when cyclophosphamide is administrated in high doses.
Azin Alizadehasl, Bita Shahrami, Reza Rahbarghazi, Azam Yalameh Aliabadi, Seyedeh Fatemeh Hosseini Jebelli, Yasamin Afsari Zonooz, Hoda Hakimian, Farzaneh Fathi, Sara Forati, Aysa Rezabakhsh   +9 more
doaj   +1 more source

Cognitive impairment and elevated peripheral cytokines in breast cancer patients receiving chemotherapy

Arquivos de Neuro-Psiquiatria, 2022
Background Anthracyclines-based regimen (5-fluorouracil, doxorubicin, and cyclophosphamide (FAC); cyclophosphamide, epirubicin, and 5-fluorouracil [CEF]) and non-anthracycline based regimens (cyclophosphamide, methotrexate, and 5-fluorouracil [
Mohd Ashif Khan, Dinesh Bhurani, Ubedul Hoda, Nouroz Sehar, Nidhi Agarwal   +4 more
doaj   +1 more source

Single low-dose cyclophosphamide combined with interleukin-12 gene therapy is superior to a metronomic schedule in inducing immunity against colorectal carcinoma in mice [PDF]

, 2012
The use of conventional cytotoxic agents at metronomic schedules, alone or in combination with targeted agents or immunotherapy, is being explored as a promising anticancer strategy.
Alaniz, Laura Daniela, Aquino, Jorge Benjamin, Atorrasagasti, María Catalina, Bayo Fina, Juan Miguel, Fiore, Esteban Juan, García, Mariana Gabriela, Malvicini, Mariana, Matar, Pablo, Mazzolini Rizzo, Guillermo Daniel, Piccioni, Flavia Valeria   +9 more
core   +1 more source

N-acetylcysteine modulates cyclophosphamide-induced immunosuppression, liver injury, and oxidative stress in miniature pigs

Journal of Animal Science and Technology, 2020
Cyclophosphamide, a cytotoxic anticancer agent, induces immunosuppression and has several adverse effects. N-acetylcysteine alleviates oxidative stress, liver injury, and intestinal tissue damage. The present study
Kyung Soo Kang, Sangsu Shin, Sang In Lee
doaj   +1 more source

The Effect of Cyclophosphamide Chemotherapy on Ovarian AntiMüllerian Hormone Levels in Breast Cancer Patients

Indonesian Journal of Obstetrics and Gynecology, 2018
Objective: To evaluate cyclophosphamide effects on Anti- Müllerian hormone (AMH) levels in breast cancer patients treated with cyclophosphamide chemotherapy. Methods: This cohort prospective study was conducted in Dr.
Elisabeth G.K. Liga, Nusratuddin Abdullah, Eddy Tiro, St. Maisuri T. Chalid   +3 more
doaj   +1 more source

Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children and young adults with relapsed and refractory solid tumors. [PDF]

, 2016
PurposeTo determine the maximum tolerated dose (MTD), toxicities, and pharmacodynamics effects of sirolimus combined with oral metronomic topotecan and cyclophosphamide in a pediatric population.Materials and methodsPatients who were 1 to 30 years of age
Allen, Shelly, DuBois, Steven G, Gustafson, W Clay, Hollinger, Fabienne, Karski, Erin E, Long-Boyle, Janel R, Matthay, Katherine K, Nasholm, Nicole M, Shiboski, Stephen, Vo, Kieuhoa T   +9 more
core   +1 more source

Rapamycin Prevents cyclophosphamide-induced Over-activation of Primordial Follicle pool through PI3K/Akt/mTOR Signaling Pathway in vivo

Journal of Ovarian Research, 2017
Background Primordial follicular depletion has thought to be a common adverse effect of chemotherapy especially for female of reproductive age. The study aimed to evaluate the protective effect of rapamycin on the primordial follicles and its potential ...
Linyan Zhou, Yanqiu Xie, Song Li, Yihua Liang, Qi Qiu, Haiyan Lin, Qingxue Zhang   +6 more
doaj   +1 more source

The impact of 5-hydroxytryptamine-receptor antagonists on chemotherapy treatment adherence, treatment delay, and nausea and vomiting. [PDF]

, 2015
PurposeTo determine the incidence of chemotherapy-induced nausea/vomiting (CINV) and chemotherapy treatment delay and adherence among patients receiving palonosetron versus other 5-hydroxytryptamine receptor antagonist (5-HT3 RA) antiemetics.Materials ...
Grabner, Michael, Palli, Swetha Rao, Quimbo, Ralph A, Rugo, Hope S   +3 more
core   +2 more sources

Cyclophosphamide-Induced Severe Acute Hyponatremic Encephalopathy in Patients with Breast Cancer: Report of Two Cases

Case Reports in Oncology, 2014
Background: Cyclophosphamide is an alkylating agent widely used in antineoplastic and immunosuppressive therapies. Symptomatic hyponatremia can be a rare but life-threatening complication in patients treated with cyclophosphamide.
Michelle Baker, Maurie Markman, Jiaxin Niu   +2 more
doaj   +1 more source