Results 11 to 20 of about 222,217 (297)

Cyclophosphamide-Induced Severe Acute Hyponatremic Encephalopathy in Patients with Breast Cancer: Report of Two Cases

Case Reports in Oncology, 2014
Background: Cyclophosphamide is an alkylating agent widely used in antineoplastic and immunosuppressive therapies. Symptomatic hyponatremia can be a rare but life-threatening complication in patients treated with cyclophosphamide.
Michelle Baker, Maurie Markman, Jiaxin Niu   +2 more
doaj   +2 more sources

Cyclophosphamide [PDF]

BMJ, 1963
Cyclophosphamide, a recently-developed alkylating agent that may be administered orally, intramuscularly, and intravenously, was given to 135 patients with a wide variety of malignant diseases. Significant benefit was obtained in patients with lymphomas and leukemias as well as malignant melanoma, multiple myeloma, and carcinoma of the ovaries ...
J, SOLOMON, M J, ALEXANDER, J L, STEINFELD   +2 more
openaire   +4 more sources

Nephrotoxicity Risk of Cyclophosphamide in Lupus Model [PDF]

, 2021
Cyclophosphamide is one of the standard therapies for lupus, especially lupus nephritis based on its immunosuppressive effect. However, cyclophosphamide is also known as a nephrotoxic agent.
Niken Indriyanti
core   +2 more sources

The Role of curcumin extract in Ameliorating Cyclophosphamide-Induced Cardiotoxicity [PDF]

, 2023
Cyclophosphamide, a chemotherapeutic and immunosuppressive drug, has been linked to problems after bone marrow transplantation in the past. More recently, it has been demonstrated that cardiotoxicity limits the dose of cyclophosphamide, and cardiology is
Jaffat Haider Salih, Hala Baqer Thanoon Al-Bayati, Haider Salih Jaffat, Thanoon Al-Bayati Hala Baqer   +3 more
core   +2 more sources

A study of ovarian cancer patients treated with dose-intensive chemotherapy supported with peripheral blood progenitor cells mobilised by filgrastim and cyclophosphamide [PDF]

, 1996
Summary We have shown that large numbers of haemopoietic progenitor cells are mobilised into the blood after filgrastim [granulocyte colony-stimulating factor (G-CSF)] alone and filgrastim following cyclophosphamide chemotherapy in previously untreated
Dexter, TM, C Gill, D Crowther, Gill, C, NG Testa, Weaver, A, Testa, NG, A Weaver, B Jenkins, R Pettengell, Collins, CD, Crowther, D, A Watson, Pettengell, R, Wrigley, E, J Chang, TM Dexter, Watson, A, CD Collins, E Wrigley, Chang, J, Jenkins, B   +21 more
core   +1 more source

THE ANTITOXIC EFFECT OF THE ROSUVASTATIN IN THE CYCLOPHOSPHAMIDE-INDUCED LIVER TOXICITY IN MALE RATS [PDF]

Assiut Veterinary Medical Journal
The study aims to examine the protective effect of rosuvastatin on liver toxicity caused by cyclophosphamide, including tissue, inflammatory markers, and oxidative damage. Twenty-four rats were separated into three distinct groups.
RANA ATTARBASHEE
doaj   +1 more source

Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth [PDF]

, 2009
Background: Anti-cancer chemotherapy can be simultaneously lymphodepleting and immunostimulatory. Pre-clinical models clearly demonstrate that chemotherapy can synergize with immunotherapy, raising the question how the immune system can be mobilized to ...
Amy Prosser, Robinson, B.W.S., Currie, A.J., Scalzo, A.A., Joanne Salmons, Robbert G van der Most, Mark J Smyth, Bruce W S Robinson, Salmons, J., Lake, R.A., Smyth Mark J., Andrew J Currie, Amanda L Cleaver, Prosser, Amy, van der Most, R.G., Degli-Esposti, M.A., Salmons, Joanne, Lake, Richard A., Prosser, A., Prosser Amy, Nowak, A.K., Currie, Andrew J., van der Most Robbert G., Smyth, M.J., Robinson Bruce W. S., Lake Richard A., Degli-Esposti, Mariapia A., Scalzo Anthony A., Currie Andrew J., Nowak, Anna K., Sathish Mahendran, Cleaver, Amanda L., Richard A Lake, Nowak Anna K., van der Most, Robbert G., Larma, I., Mahendran, S., Anna K Nowak, Degli-Esposti Mariapia A., Anthony A Scalzo, Cleaver, A.L., Robinson, Bruce W.S., Larma, Irma, Irma Larma, Cleaver Amanda L., Smyth, Mark J., Larma Irma, Mehendran, Sathish, Scalzo, Anthony A., Salmons Joanne, Mahendran Sathish, Mariapia A Degli-Esposti   +51 more
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Metabolism of cyclophosphamide [PDF]

Cancer, 1967
The in vivo activation of cyclophosphamide (Endoxan) to cytostatic and alkylating metabolites has been studied. Endoxan is metabolized to the weak anion by microsomal dealkylation in the rat's liver; this product is the first alkylating metabolite.
N, Brock, H J, Hohorst
openaire   +2 more sources

N-acetylcysteine modulates cyclophosphamide-induced immunosuppression, liver injury, and oxidative stress in miniature pigs

Journal of Animal Science and Technology, 2020
Cyclophosphamide, a cytotoxic anticancer agent, induces immunosuppression and has several adverse effects. N-acetylcysteine alleviates oxidative stress, liver injury, and intestinal tissue damage. The present study
Kyung Soo Kang, Sangsu Shin, Sang In Lee
doaj   +1 more source

Post-transplant cyclophosphamide-induced cardiotoxicity: A comprehensive review [PDF]

Journal of Cardiovascular and Thoracic Research
Cyclophosphamide-induced cardiotoxicity, associated with its toxic metabolite acrolein, is a significant concern and unresolved issue, especially when cyclophosphamide is administrated in high doses.
Azin Alizadehasl, Bita Shahrami, Reza Rahbarghazi, Azam Yalameh Aliabadi, Seyedeh Fatemeh Hosseini Jebelli, Yasamin Afsari Zonooz, Hoda Hakimian, Farzaneh Fathi, Sara Forati, Aysa Rezabakhsh   +9 more
doaj   +1 more source