Results 101 to 110 of about 709,838 (360)

Analysis of isolated loco-regional recurrence rate in intermediate risk early cervical cancer after a type C2 radical hysterectomy without adjuvant radiotherapy

International Journal of Gynecological Cancer, 2019
Background The efficacy of adjuvant radiotherapy in patients with intermediate risk early cervical cancer after radical hysterectomy is still under debate.
J. van der Velden, C. Mom, L. V. van Lonkhuijzen, M. Tjiong, H. Westerveld, G. Fons   +5 more
semanticscholar   +1 more source

Severe and prolonged myelosuppression during concomitant temozolomide and radiotherapy treatment in a patient with glioblastoma multiforme [PDF]

, 2015
Aims: We describe the case of a patient with glioblastoma (GBM) who developed severe and prolonged myelosuppression during concomitant daily temozolomide (TMZ) and radiotherapy (RT) treatment.
ALOE SPIRITI, Maria Antonietta, Carnevale, Alessia, Cox, Maria, DE SANCTIS, Vitaliana, Gentile, Giovanna, MAURIZI ENRICI, Riccardo, Minniti, Giuseppe, Porrini, ì Raffaele, Ruco, Luigi, Scaringi, Claudia, Simmaco, Maurizio, Tafuri, Agostino, Valeriani, Maurizio   +12 more
core   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Identification and validation of single-sample breast cancer radiosensitivity gene expression predictors

Breast Cancer Research, 2018
Background Adjuvant radiotherapy is the standard of care after breast-conserving surgery for primary breast cancer, despite a majority of patients being over- or under-treated.
Martin Sjöström, Johan Staaf, Patrik Edén, Fredrik Wärnberg, Jonas Bergh, Per Malmström, Mårten Fernö, Emma Niméus, Irma Fredriksson   +8 more
doaj   +1 more source

The role of chemotherapy in the management of resectable colorectal cancer [PDF]

Archive of Oncology, 2003
Adjuvant chemotherapy has been established as the standard of care for patients with node-positive resected colon cancer. 5-fluorouracil modulated with leucovorin given for six months is currently the most widely accepted "standard" regimen.
Radosavljević Davorin Z., Tomašević Zorica I., Popov Ivan, Jelić Svetislav B.   +3 more
doaj   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Postoperative radiotherapy after conservative surgery for early breast cancer: 5-year results [PDF]

Archive of Oncology, 2004
BACKGROUND: Breast conserving surgery followed by postoperative radiotherapy, as alternative to radical mastectomy, has been accepted as an optimal method for loco- regional treatment of the majority of women with early stage of breast carcinoma. The aim
Mladenović Jasmina, Dožić Marko, Borojević Nenad D.   +2 more
doaj   +1 more source

Integration of patient-reported outcome measures with key clinical outcomes after immediate latissimus dorsi breast reconstruction and adjuvant treatment

, 2013
Background: linical evidence on patient-reported outcome measures (PROMS) in breast reconstruction is lacking. The aim of this study was to evaluate PROMs in implant-assisted latissimus dorsi (LDI) or tissue-only autologous latissimus dorsi (ALD) flap ...
Balta, V, Benson, J, Betambeau, N, Haviland, J, Prospective Trial Management, Grp, Reece-Smith, A, Winters, Z. E   +6 more
core   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

A volumetric Modulated Arc Therapy (VMAT) combined with deep inspiration breath hold (DIBH) technique for adjuvant irradiation for left sided breast cancer [PDF]

arXiv, 2017
Background: The deep inspiration breath hold technique (DIBH) is widely used for left-sided breast radiotherapy (RT), in order to reduce the dose to the heart and the risk of cardiotoxicity. The volumetric arc therapy (VMAT) technique increases the dose conformity to the planning target volume (PTV).
arxiv