Results 101 to 110 of about 791,952 (357)

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Outcome of high grade gliomas–An institutional experience

Acta Medica International, 2017
Objective: In this study we evaluated the prognostic factors, dosimetry and survival outcome of high grade gliomas receiving radiotherapy with concurrent temozolomide and with or without adjuvant temozolomide.
Nagarjuna Burela, Nidhi Patni
doaj   +1 more source

Comparison of adjuvant versus salvage radiotherapy policies for postprostatectomy radiotherapy

International Journal of Radiation Oncology*Biology*Physics, 2004
We compared the long-term results of postprostatectomy radiotherapy (RT) from two institutions, one adapting a prospective policy of adjuvant RT and the other salvage RT.Between 1989 and 1997, 69 patients were referred for adjuvant RT to the institution using adjuvant RT and 88 patients with evidence of recurrence were treated in the institution using ...
Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA ( host institution ), Hagan, Michael ( author ), Zlotecki, Robert ( author ), Medina, Camillo ( author ), Tercilla, Oscar ( author ), Rivera, Inoel ( author ), Wajsman, Zev ( author )   +6 more
openaire   +3 more sources

Close Margins and Adjuvant Radiotherapy in Acinic Cell Carcinoma of the Parotid Gland

JAMA Otolaryngology - Head and Neck Surgery, 2018
Importance The precise indications and oncologic effects of adjuvant radiotherapy in acinic cell carcinoma of the parotid gland are not well known, particularly in patients with negative, but close (⩽1 mm), margins without other high-risk histopathologic
J. Zenga, A. S. Parikh, K. Emerick, D. Lin, W. Faquin, D. Deschler   +5 more
semanticscholar   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

The clinical target volume delineation of para aortic lymph node region for adjuvant radiotherapy based on the regularity of lymph node metastasis in biliary tract cancer [PDF]

, 2022
Ying Wang, Han Wu, Jin Peng, Lei Yang, Hui Xu, Jing Dai, Wenbo Wang, Ling Xia, Fuxiang Zhou   +8 more
openalex   +1 more source

Adjuvant Radiotherapy in Breast Cancer [PDF]

Breast Care, 2006
Locoregional external beam radiation therapy using linear accelerators is an essential component of a multimodal treatment concept with a curative intent after primary surgical therapy in non-invasive and locally confined invasive breast cancer. Its important role has been confirmed at the highest level of evidence by recent results of prospective ...
openaire   +1 more source

Comparison between adjuvant chemotherapy and adjuvant radiotherapy/chemoradiotherapy after radical surgery in patients with cervical cancer: a meta-analysis

Journal of Gynecologic Oncology, 2018
Objective To estimate the effect of adjuvant chemotherapy (AC) on the prognosis in cervical cancer patients with intermediate- or high-risk factors after radical hysterectomy (RH) compared to that for adjuvant radiotherapy (AR).
Kwang-Beom Lee, S. Shim, Jong Min Lee
semanticscholar   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source