Results 51 to 60 of about 164,514 (305)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Adjuvant radiotherapy with brachytherapy boost in soft tissue sarcomas [PDF]

, 2017
Purpose: The standard primary treatment for soft tissue sarcoma (STS) is a wide surgical resection, preceded or followed by radiotherapy. Purpose of this retrospective study was to assess the efficacy of perioperative brachytherapy (BRT) plus ...
Gambarotti, Marco, Silvia Cammelli, Ferrari, Stefano, Gian Carlo Mattiucci, Alessandra Arcelli, Cilla, Savino, Morganti, Alessio Giuseppe, Valentini, Vincenzo, Galuppi, Andrea, Marco Gambarotti, Macchia, Gabriella, Francesco Deodato, Alberto Righi, Stefano Ferrari, Alessio Giuseppe Morganti, Frakulli, Rezarta, Ferraro, Andrea, Cortesi, Annalisa, Buwenge, Milly, Andrea Ferraro, Giuseppe Bianchi, Fabrizio Romani, Davide Donati, Farioli, Andrea, Righi, Alberto, Deodato, Francesco, Savino Cilla, Annalisa Cortesi, Romani, Fabrizio, Andrea Farioli, Bianchi, Giuseppe, Gabriella Macchia, Milly Buwenge, Vincenzo Valentini, Cammelli, Silvia, Andrea Galuppi, Arcelli, Alessandra, Donati, Davide, Rezarta Frakulli, Mattiucci, Gian Carlo   +39 more
core   +1 more source

Delineation of the Prostate Bed: The “Invisible Target” Is Still an Issue?

Frontiers in Oncology, 2017
For pathological high-risk prostate cancer, adjuvant irradiation has shown a survival benefit. Phase III studies have highlighted that half men would face biochemical relapse and would be candidate for radiotherapy at adjuvant or salvage times.
Igor Latorzeff, Paul Sargos, Geneviève Loos, Stéphane Supiot, Stéphane Guerif, Christian Carrie   +5 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Prognostic role of adjuvant radiotherapy in triple-negative breast cancer: A historical cohort study

, 2015
The value of adjuvant radiotherapy in triple-negative breast cancer (TNBC) is currently debated. We assessed the association between adjuvant radiotherapy and survival in a large cohort of Asian women with TNBC.
Hartman, Mikael, Nur Aishah Taib, Nei, Wen-Long, Tan, Ern-Yu, Taib, NA, Verkooijen, Helena M., Jean‐Philippe Pignol, Gwo‐Fuang Ho, Yip, Cheng-Har, Tan, B, Ho, Gwo-Fuang, Cheng‐Har Yip, Wen‐Long Nei, Dent, R, Bhoo-Pathy, N, Kwong, A, Wong, Fuh-Yong, Chan, Patrick, Lee, Soo-Chin, Benita Tan, Tan, EY, Bhoo Pathy, Nirmala, Nei, WL, Hartman, M, Tan, Benita, Mikael Hartman, Lee, SC, Chan, P, Taib, Nur Aishah, Yip, CH, Soo‐Chin Lee, Ava Kwong, Dent, Rebecca, Nirmala Bhoo‐Pathy, Wong, FY, Ho, GF, Patrick Chan, Rebecca Dent, Fuh‐Yong Wong, Ern‐Yu Tan, Kwong, Ava, Verkooijen, HM, Pignol, Jean-Philippe, Helena M. Verkooijen   +43 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue [PDF]

, 2014
Five-year survival for patients with oral cancer has been disappointingly stable during the last decades, creating a demand for new biomarkers and treatment targets.
Philip John Coates, Torben Wilms, Laurell, Göran,, Rentoft, Matilda,, Coates, Philip John, Matilda Rentoft, Lotta Loljung, Göran Laurell, Karin Nylander, Rentoft, Matilda, Laurell, Göran, Wilms, Torben, Loljung, Lotta, Nylander, Karin, Loljung, Lotta,, Wilms, Torben,, Nylander, Karin,, Coates, Philip John,   +17 more
core   +1 more source

Does chemotherapy or radiotherapy affect the postoperative complication in breast cancer patients who underwent immediate breast reconstruction with tissue expander?

BMC Cancer, 2021
Background Immediate breast reconstruction with tissue expander in breast cancer patients who were expected to receive adjuvant therapy, such as chemotherapy or radiotherapy, has been a topic of debate.
Sung Mi Jung, Byung-Joon Jeon, Jinsun Woo, Jai Min Ryu, Se Kyung Lee, Byung-Joo Chae, Jonghan Yu, Seok Won Kim, Seok Jin Nam, Jai-Kyong Pyon, Goo-Hyun Mun, Sa Ik Bang, Jeong Eon Lee   +12 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source