Results 61 to 70 of about 164,514 (305)

The Pathophysiological effects of adjuvant preoperative chemotherapy and/or radiotherapy on patients with advanced rectal cancer [PDF]

, 2013
Introduction The modern treatment of colorectal cancer consists of surgery, with or without adjuvant pre-operative radiotherapy, chemotherapy or chemoradiotherapy (APT) for selected cases. In the United Kingdom, therapy may be given prior to surgery in
Rahmani, Samir
core  

Prognostic Role of Adjuvant Radiotherapy in Patients With pT1-2N1-2b Oropharyngeal Squamous Cell Carcinoma

Journal of Otolaryngology - Head and Neck Surgery
Importance The necessity of adjuvant radiotherapy in patients with pT1-2N1-2b oropharyngeal squamous cell carcinoma (OPSCC) remains unclear. Objective To examine the prognostic role of adjuvant radiotherapy in patients with either p16-positive or p16 ...
Liang Peng MD, Lin Chen MD, Zhang-Feng Wang MD, Xiao-Lin Zhu MD, Wei Sun MD, Wei-Ping Wen MD, Wen-Bin Lei MD   +6 more
doaj   +1 more source

Prognostic analysis of stage Ⅰ lung cancer based on SEER data

Zhongguo linchuang yanjiu
Objective To explore the clinical characteristics and treatment methods that affect the prognosis of stage Ⅰlung cancer. Methods Clinical data of stage Ⅰ lung cancer patients diagnosed and treated with radical surgical resection from 2019 to 2021 were ...
LI Xiaowu，YUAN Yuan，HAN Liang
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Meta-analysis of the influence of surgical margin and adjuvant radiotherapy on local recurrence after resection of sporadic desmoid-type fibromatosis

, 2017
Background Extra-abdominal desmoid-type fibromatosis (DF) is a rare, locally aggressive neoplasm that is usually managed conservatively.
van Broekhoven, D L M, D L M van Broekhoven, Grünhagen, D J, A Gronchi, D J Grünhagen, Bonvalot, S, J J Nuyttens, Verhoef, C, Grünhagen, D J; id_orcid, Cates, J M M, S Bonvalot, Gronchi, A, Nuyttens, J J, J M M Cates, Bramer, W M, C Verhoef, Salas, S, M L Janssen, W M Bramer, S Salas, Janssen, M L   +20 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Incidence of radiation toxicity in cervical cancer and endometrial cancer patients treated with radiotherapy alone versus adjuvant radiotherapy

, 2012
AimThe study was made to evaluate early and late toxicity in a diversified group of patients receiving definitive or adjuvant radiotherapy in terms of clinical diagnosis and treatment methods.BackgroundRadiotherapy is a standard way of treatment in ...
Wareńczak-Florczak, Żaneta; Greater Poland Cancer Centre, Department of Gynaecological Radiotherapy and Oncology, Garbary Street 15, 61-866 Poznan, Poland, Roszak, Andrzej; Greater Poland Cancer Centre, Department of Gynaecological Radiotherapy and Oncology, Garbary Street 15, 61-866 Poznan, Poland; Department of Electroradiology, University of Medical Sciences, Poznan, Poland, Bratos, Krystyna; Greater Poland Cancer Centre, Department of Gynaecological Radiotherapy and Oncology, Garbary Street 15, 61-866 Poznan, Poland, Milecki, Piotr; Department of Electroradiology, University of Medical Sciences, Poznan, Poland; Greater Poland Cancer Centre, Department of Radiation Oncology, Garbary Street 15, 61-866 Poznan, Poland   +3 more
core   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Subgroup analysis of OS stratified by adjuvant radiotherapy and chemoradiotherapy.

, 2020
A, adjuvant radiotherapy; B, adjuvant chemoradiotherapy.
Lei Wang (6656), Nanping Lin (8478612), Manjun Deng (8478615), Qiao Ke (8478609), Jingfeng Liu (1392460), Yongyi Zeng (1392457)   +5 more
core   +1 more source