Results 231 to 240 of about 58,448 (306)

Advancing Cancer Cachexia Drug Development: Leveraging Biomarkers and Functional Endpoints to Optimize Trial Design

open access: yesCancer Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background Cancer‐associated cachexia is a complex, multistage metabolic disorder that markedly contributes to morbidity and mortality in patients with advanced cancer, yet effective pharmacological interventions are lacking. Cachexia drug development has expanded significantly in recent years, with multiple repurposed agents and novel ...
Nada O. Othman   +3 more
wiley   +1 more source

Understanding the Molecular Landscape of Alopecia Areata: Key Genes, Regulatory Networks, and Therapeutic Targets

open access: yesHealth Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Introduction Alopecia areata (AA) is an autoimmune disorder characterized by hair loss due to immune‐mediated destruction of hair follicles. The polygenic nature of AA, influenced by genetic and environmental factors, complicates its pathogenesis.
Ahmed Ibrahim AbdElneam   +4 more
wiley   +1 more source

Quantitative Muscle MRI of the Lower Extremities Reveals Different Patterns of Involvement in Classic Infantile and Young Late‐Onset Pompe Patients

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT With increased survival due to enzyme replacement therapy, children with classic infantile Pompe disease tend to develop a clinical phenotype with pronounced distal muscle weakness, while late‐onset patients typically exhibit proximal muscle weakness.
Jan J. A. van den Dorpel   +7 more
wiley   +1 more source

NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions. [PDF]

open access: yesNat Metab
Radyk MD   +22 more
europepmc   +1 more source

Posterior tibial slope varies across functional tibial phenotypes but not CPAK categories: A radiographic analysis from the FP‐UCBM Knee Study Group

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, Volume 34, Issue 7, Page 2462-2468, July 2026.
Abstract Purpose The relationship between the coronal and sagittal planes of the knee remains largely unexplored. The aim of this study was to evaluate the correlation between Posterior Tibial Slope (PTS), Hirschmann's functional tibial phenotypes, CPAK categories, and their defining parameters, hypothesising that coronal and sagittal tibial parameters
Edoardo Franceschetti   +9 more
wiley   +1 more source

Natural Products as Modulators of ABC Transporters in Breast Cancer

open access: yesPhytotherapy Research, Volume 40, Issue 7, Page 4611-4637, July 2026.
ABSTRACT Breast cancer remains a significant global health challenge, with high incidence and mortality rates despite advancements in early detection and treatment. Multidrug resistance (MDR), particularly in aggressive subtypes like triple‐negative breast cancer (TNBC), continues to hinder effective therapy.
Yoganishalini Sagadevan   +2 more
wiley   +1 more source

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