Results 211 to 220 of about 28,615 (245)

Development of an Insulin Nano-delivery System through Buccal Administration

Current Drug Delivery, 2022
Aim: The aim of the study was to develop a new nano-delivery system for buccal administration of insulin. Background: Biodegradable polymeric nanoparticles (PNPs) had undergone countless breakthroughs in drug delivery systems. The main objective of PNPs application in delivering and carrying different promising drugs is to make sure that the drugs ...
Ayat Bozeya, Diaa Al-Domi, Mohamed Al-Fandi   +2 more
openaire   +2 more sources

Sublingual and buccal drug administration in medical emergencies

Medicina Clínica (English Edition)
Drug administration is crucial to achieve effective therapeutic drug outcomes. In medical emergencies, it is particularly convenient to use drugs that could be administered as an alternative to traditional routes (as oral or intravenous routes), that are not always suitable in these situations. Thus, sublingual and buccal routes offer an alternative to
Joan Ramon, Roma, Pedro, Castro Rebollo, Carla, Bastida   +2 more
openaire   +2 more sources

Buccal administration of dexmedetomidine as a preanesthetic in children

Journal of Anesthesia, 2010
The objective of this study was to evaluate the efficacy and safety of buccal dexmedetomidine as a preanesthetic in children, to compare it with diazepam, and to investigate the optimal dosage for buccal dexmedetomidine administration by measuring its serum concentration.We performed a prospective study with 40 children who were assigned to two groups.
Yoshio, Sakurai, Toru, Obata, Akio, Odaka, Katsuo, Terui, Masanori, Tamura, Hideki, Miyao   +5 more
openaire   +2 more sources

Systemic uptake of buprenorphine after buccal administration in cats

Veterinary Anaesthesia and Analgesia, 2002
Administration of drugs to cats can be challenging and simple but effective techniques would be attractive to the owners. The purpose of this study was to compare the pharmacokinetics of buprenorphine (B) after buccal administration, and compare these to data previously collected from the same colony of cats after IV and IM injection.
S A, Robertson, P M, Taylor, M, Bloomfield, J W, Sear   +3 more
openaire   +2 more sources

Drug Delivery Approaches for Buccal and Sublingual Administration

Drug Research
AbstractBoth local and systemic medication delivery benefit greatly from the sublingual and buccal modes of administration. They have shown to be a successful substitute for the conventional oral route, particularly in situations requiring a quick commencement of action. Via venous drainage to
Asad, Ahmad, Juber, Akhtar, Mohammad, Ahmad, Rufaida, Wasim, Mohammad Irfan, Khan   +4 more
openaire   +2 more sources

Development of mucoadhesive patches for buccal administration of ibuprofen

Journal of Controlled Release, 2004
A new formulation for topical administration of drugs in the oral cavity has been developed using several film-forming and mucoadhesive polymers. The films have been evaluated in terms of swelling, mucoadhesion and organoleptic characteristics. The best film, containing polyvinylpyrrolidone (PVP) as film-forming polymer and carboxymethylcellulose ...
PERIOLI, Luana, AMBROGI, Valeria, Angelici F., RICCI, Maurizio, GIOVAGNOLI, Stefano, Capuccella M., ROSSI, Carlo   +6 more
openaire   +3 more sources

Pharmacokinetics of Ciclopirox Olamine after Buccal Administration in Rabbits

Current Drug Delivery, 2017
Prevalence of oral mucosal fungal infections increases with the frequent administration of antibiotics, corticosteroids and immunosuppressive drugs. Therapeutically used antifungals are usually associated with a variety of drug interactions.
Ivana, Lukášová, Jan, Muselík, David, Vetchý, Jan, Gajdziok, Markéta, Gajdošová, Jan, Juřica, Zdeněk, Knotek, Karel, Hauptman, Vladimír, Jekl   +8 more
openaire   +2 more sources

Absorption behavior of etilefrine after buccal administration in rats

International Journal of Pharmaceutics, 2018
Etilefrine hydrochloride (ET-HCl) is used in the treatment of hypotension. Dosage forms of orally administered tablets and parenteral injections are clinically available, but exhibit unfavorable characteristics, including cardiac toxicity, headaches, and damage at the injection site for the parenteral dosage form, and initially high plasma levels, fast
Hiraku, Onishi, Osamu, Sakata
openaire   +2 more sources

Pharmacokinetics of testosterone after percutaneous gel or buccal administration

Fertility and Sterility, 2001
To determine the pharmacokinetics of testosterone following its administration using transdermal gel or buccal lozenges.Pilot study.University-based hospital.Ten bilaterally oophorectomized women.Daily micronized testosterone gel (1 mg) and testosterone propionate lozenge (1 mg).Total testosterone, androstenedione, dihydrotestosterone, 3alpha ...
C C, Slater, I, Souter, C, Zhang, C, Guan, F Z, Stanczyk, D R, Mishell   +5 more
openaire   +2 more sources

Development of Mucoadhesive Patches for Buccal Administration of Carvedilol

Current Drug Delivery, 2007
A buccal patch for systemic administration of carvedilol in the oral cavity has been developed using two different mucoadhesive polymers. The formulations were tested for in vitro drug permeation studies, buccal absorption test, in vitro release studies, moisture absorption studies and in vitro bioadhesion studies.
Y Vamshi, Vishnu, K, Chandrasekhar, G, Ramesh, Y Madhusudan, Rao   +3 more
openaire   +2 more sources