Results 61 to 70 of about 49,397 (289)

Mucoadhesive Tablets for Buccal Administration Containing Sodium Nimesulide

Drug Delivery, 2004
The possibility of improving the flux of nimesulide across the buccal mucosa using the drug in the form of a sodium salt was investigated in our study. The salt form may increase to flux across buccal membrane, starting from a suspension; its lower permeation coefficient is compensated by a higher concentration gradient.
MAFFEI, PAOLA, LOMBARDI BORGIA, SIMONE, SFORZINI, ANNALISA, BERGAMANTE, VALENTINA, CESCHEL, GIANCARLO, FINI, ADAMO, RONCHI C.   +6 more
openaire   +5 more sources

New Non-Intravenous Routes for Benzodiazepines in Epilepsy: A Clinician Perspective. [PDF]

, 2017
Benzodiazepines represent the first-line treatment for the acute management of epileptic seizures and status epilepticus. The emergency use of benzodiazepines must be timely, and because most seizures occur outside of the hospital environment, there is a
A Thakker, B Abou-Khalil, B Talukdar, C Bitter, C Lehmann, CKK Malu, D Harris, DJ Greenblatt, DP Wermeling, E Lahat, E Lahat, F Brigo, GJ Haan de, H Meierkord, HG Eder, HR McKee, I Shah, IE Leppik, J Blakeley, J McIntyre, J Rogin, JH McDonough, JJ Lochhead, JM Chamberlain, KO Nakken, LY Xi, M Bhattacharyya, M Holsti, M Holsti, M Mula, M Scheepers, Marco Mula, MR Ashrafi, National Institute for Health and Care Excellence, P Mittal, PM Brennan, R Arya, R Kälviäinen, R Silbergleit, R Silbergleit, RC Scott, RC Scott, RC Scott, RD Welch, RS Fisher, S Ahmad, S Baysun, S Wait, T Fisgin, T Mahmoudian   +49 more
core   +1 more source

Bionic Microneedle Patch Inspired by Drosophila Tarsal Paws Boosts Healing in Bacterial Infectious Stomatitis

Advanced Science, EarlyView.
Microneedle suction cup patches, prepared using bionic Drosophila tarsal claws, can effectively treat bacterial infectious stomatitis by rapidly and efficiently leveraging multiple effects, including antibacterial and anti‐inflammatory properties, promotion of vasodilation, and active mechanical contraction of the wound.
Jiaqi Qin, Cewen Hu, Xiaohong Ran, Huajing Zeng, Jie Zhang, Bin Liu, Zengjie Fan   +6 more
wiley   +1 more source

Medication Abortion: A Sample Protocol for Increasing Access During a Pandemic and Beyond [PDF]

, 2021
No ...
Atrio, Jessica, Coplon, Leah, Creinin, Mitchell, Dean, Gillian, Gold, Marji, Grossman, Daniel, Mark, Alice, Perritt, Jamila, Raymond, Elizabeth, Taylor, DeShawn, Upadhyay, Ushma   +10 more
core  

Sleep Deprivation Activates a Conserved Lactate‐H3K18la‐RORα Axis Driving Neutrophilic Inflammation Across Species

Advanced Science, EarlyView.
Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou, Keyun Li, Xiezong Hu, Shuhao Fan, Yuxuan Gao, Xiaoshu Xue, Yu Bu, Haoyi Zhang, Yili Wang, Chunjiao Wei, Shangrong Zhang, Zhongwen Xie, Chao Liu, Peng Chen, Zongjun Yin, Dalong Ren   +15 more
wiley   +1 more source

New Technological Approaches for Dental Caries Treatment: From Liquid Crystalline Systems to Nanocarriers

Pharmaceutics, 2023
Dental caries is the most common oral disease, with high prevalence rates in adolescents and low-income and lower-middle-income countries. This disease originates from acid production by bacteria, leading to demineralization of the dental enamel and the ...
Marcela Tavares Luiz, Leonardo Delello di Filippo, Jessyca Aparecida Paes Dutra, Juliana Santos Rosa Viegas, Amanda Letícia Polli Silvestre, Caroline Anselmi, Jonatas Lobato Duarte, Giovana Maria Fioramonti Calixto, Marlus Chorilli   +8 more
doaj   +1 more source

Adipose Tissue Macrophages as Initiators of Exacerbated Periodontitis in Estrogen‐Deficient Environments via the Amplifier Extracellular Vesicles

Advanced Science, EarlyView.
Chronic systemic inflammation, worsened by estrogen deficiency, underlies and exacerbates periodontitis. Proinflammatory macrophages within visceral adipose tissue are hyperactivated due to hyper‐DNA methylation, releasing small extracellular vesicles (sEVs) similar to those of their parent cells.
Danfeng Li, Tian Yang, Yuqian Li, Xinwei Lyu, Cheng Hu, Jiayin Yan, Jiali Tan   +6 more
wiley   +1 more source

Amlodipine-induced buccal lichenoid lesions: A case report [PDF]

Malaysian Family Physician
Buccal lichenoid lesions (BLLs) are characterised by a unique, linear whitish striation in the buccal region and can be accompanied by ulcers, plaques, erythemas, atrophies and blisters.
Muhammad Hafiz Mohamed Pauzi, Azidah Abdul Kadir, Zainab Mat Yudin   +2 more
doaj   +1 more source

Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine

Frontiers in Pharmacology, 2023
Recently, the Amazonian plant medicine “ayahuasca”—containing the psychedelic compound N,N-dimethyltryptamine (DMT) and numerous β-carboline alkaloids, such as harmine—has been suggested to exhibit beneficial effects in patients with affective and other ...
Dario A. Dornbierer, Dario A. Dornbierer, Dario A. Dornbierer, Laurenz Marten, Laurenz Marten, Jovin Mueller, Helena D. Aicher, Helena D. Aicher, Helena D. Aicher, Michael J. Mueller, Michael J. Mueller, Michael J. Mueller, Martina Boxler, Michael Kometer, Davor Kosanic, Robin von Rotz, Maxim Puchkov, Thomas Kraemer, Hans-Peter Landolt, Hans-Peter Landolt, Erich Seifritz, Erich Seifritz, Milan Scheidegger, Milan Scheidegger   +23 more
doaj   +1 more source

Nicotine-replacement therapy: A proven treatment for smoking cessation [PDF]

, 2010
Smoking is a major cause of cardiovascular diseases, respiratory diseases and cancer. Despite the high prevalence of smokers worldwide, smokers are often neglected and not offered effective assistance with quitting their habits. In order to overcome this
Robson, Noorzurani
core   +1 more source