Results 181 to 190 of about 1,796,663 (223)

Serum steroid levels during 12-week intravaginal dehydroepiandrosterone administration

Menopause, 2009
Because a previous 1-week study has shown no or minimal changes in the serum levels of dehydroepiandrosterone (DHEA) and its metabolites after up to daily 1.8% (23.4 mg) intravaginal DHEA, the objective of the present study was to investigate the serum steroid levels during a 12-week daily intravaginal administration of 0%, 0.25%, 0.5%, and 1.0% DHEA ...
Fernand, Labrie, David, Archer, Céline, Bouchard, Michel, Fortier, Leonello, Cusan, José-Luis, Gomez, Ginette, Girard, Mira, Baron, Normand, Ayotte, Michèle, Moreau, Robert, Dubé, Isabelle, Côté, Claude, Labrie, Lyne, Lavoie, René, Bérubé, Patrick, Bélanger, Louise, Berger, Lucy, Gilbert, Céline, Martel, John, Balser   +19 more
openaire   +2 more sources

Medicated Tampons: Intravaginal Sustained Administration of Metronidazole and In Vitro-In Vivo Relationships

Journal of Pharmaceutical Sciences, 1982
The technical feasibility of utilizing tampons as a drug delivery system for prolonged intravaginal drug administrations was studied. Several commercially available brands of tampons were examined. The methodology for the incorporation of various doses of metronidazole, an antitrichomonas agent, in tampons was described.
Y W, Chien, J, Oppermann, B, Nicolova, H J, Lambert   +3 more
openaire   +2 more sources

Radioimmunoassay of serum d-norgestrel in women following oral and intravaginal administration

Contraception, 1975
A radioimmunoassay (RIA) method for measuring d-Norgestrel (d-Ng) in serum has been developed utilizing petroleum ether extraction, an antiserum raised against d-Norgestrel3-(O-carboxymethyl) oxime-e-aminocaproic acid — bovine serum albumin, d-Norgestrel-3-(O-carboxymethyl) imino- [125I]-iodohistamine, and dextran-coated charcoal separation.
F Z, Stanczyk, M, Hiroi, U, Goebelsmann, P F, Brenner, M E, Lumkin, D R, Mishell   +5 more
openaire   +2 more sources

Mid-trimester abortion induced by intravaginal administration of prostaglandin E2 suppositories

American Journal of Obstetrics and Gynecology, 1975
Mid-trimester abortion was successfully induced in 70 of 71 patients by administration of vaginal PGE2 suppositories. The one patient who failed to abort with this method was pregnant in the blind horn of a duplex uterus. The mean abortion time for the successful inductions was 11.88 hours.
N H, Lauersen, N J, Secher, K H, Wilson
openaire   +2 more sources

Intravaginal administration of RU 486 in humans and rats: inadequate absorption in humans

Human Reproduction, 1987
Vaginal absorption of the antiprogesterone steroid RU 486 was studied in humans and rats. In rats, RU 486 was sufficiently absorbed to terminate early pregnancy following vaginal, oral or intramuscular administration. The quantitation of RU 486 in serum showed that the ratios of the areas under the concentration curves per mg administered were 1:2.8:3 ...
O, Heikinheimo, H, Croxatto, A M, Salvatierra, C C, Chang, T, Luukkainen, P, Lähteenmäki   +5 more
openaire   +2 more sources

Intravaginal Controlled Administration of Flurogestone Acetate II: Development of an In Vitro System for Studying the Intravaginal Release and Permeation of Flurogestone Acetate

Journal of Pharmaceutical Sciences, 1984
A relatively simple and easily constructed in vitro system was developed for studying the mechanism of release and intravaginal absorption of flurogestone acetate from vaginal sponges. The stability-indicating high-performance liquid chromatographic method developed earlier was used to provide a rapid, reproducible, and sensitive assay.
M B, Kabadi, Y W, Chien
openaire   +2 more sources

A STUDY OF THE VARIATION IN RESPONSE OF OVARIECTOMIZED MICE TO THE INTRAVAGINAL AND SUBCUTANEOUS ADMINISTRATION OF OESTROGENS

Journal of Endocrinology, 1954
SUMMARY From the results of two successive intravaginal tests with oestrone, mice were classified into groups having different sensitivities. These groups were more homogeneous in their responses than the parent colony, and hence the slope of the within-group dose-response lines was increased.
J D, BIGGERS, P J, CLARINGBOLD, C W, EMMENS   +2 more
openaire   +2 more sources

[Labor induction by intravaginal administration of prostaglandin E2 tablets].

Geburtshilfe und Frauenheilkunde, 1987
Between 1982 and 1984, at Graz University Obstetric and Gynaecological Clinic, labour was induced in 307 women (146 primiparae and 161 multiparae) by intravaginal administration of 3 mg prostaglandin (PG) E2 tablets, because birth was overdue or because labour was irregular.
W, Motter, G, Ralph, W, Lichtenegger, J, Haas   +3 more
openaire   +1 more source

Pharmacokinetics of triclosan in rat after intravenous and intravaginal administration.

Journal of environmental pathology and toxicology, 1979
The pharmacokinetics of triclosan was studied in sexually mature virgin Wistar rats. 14C-triclosan was injected either via the femoral vein, (iv, 5 mg/kg in polyethylene glycol-400) or into the vaginal orifice (ivg, 5 mg/kg in corn oil). Radioactivity was determined by liquid scintillation spectrophotometry.
W H, Siddiqui, H S, Buttar
openaire   +1 more source

Efficacy of intravaginal and intranasal administration of micronized estradiol-17beta.

The Journal of clinical endocrinology and metabolism, 1978
Absorption of micronized 17beta-estradiol (E2), after intravaginal administration of 1 mg dose, suspended in saline, is extremely rapid and sustained. A mean peak increment of circulating E2 concentrations of more than 110 times the basal level is achieved at 2 h and remains elevated more than 6 times the basal level even at 24 h. Increments in estrone
L A, Rigg, B, Milanes, B, Villanueva, S S, Yen   +3 more
openaire   +1 more source