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Intravenous Administration of Sodium Colistimethate

JAMA, 1964
Sodium colistimethate (Coly-Mycin Injectable) was administered intravenously to eight patients with Pseudomonas infections in doses of 2 to 2.5 mg/kg every 12 hours. Bacteriologic cure was achieved in five patients. The resulting serum concentrations of sodium colistimethate were approximately twice those obtained following intramuscular administration.
R D, BAINES, D, RIFKIND
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Pharmacoeconomics of Intravenous Drug Administration

PharmacoEconomics, 1992
Direct administration of a drug into a vein guarantees bioavailability, i.e. the total amount of drug is fully available to the bloodstream for transport to all areas of the body. What is not ensured is the safety, need and 'value for money' of this route.
S E, Parker, P G, Davey
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Intravenous Administration Sets

Archives of Internal Medicine, 1980
To the Editor. —The excellent article by Kind et al in the AprilArchives(139:413-415, 1979) heightens the need for users of intravenous administration sets to be aware of a potential danger, that of poor flow regulation and its consequences. First, here are two pertinent facts: infusion sets with conventional pinch clamps afford very poor regulation.
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