Results 221 to 230 of about 4,385,684 (306)

Extemporaneous Formulations for Pediatric Patients: Global Necessities, Challenges and Opportunities. [PDF]

Pharmaceutics
Pai VB, Nahata MC.
europepmc   +1 more source

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

Oral delivery of an ustekinumab biosimilar with bioavailability comparable to subcutaneous administration in healthy human participants. [PDF]

Eur J Clin Pharmacol
Myers JT, Yamaguchi A, Horlen K, Fung LC, Vo AT, Mohan D, Hoopes M, Imran M, Van Dam J, Gonen OM, Hashim MA, Dhalla AK, Blauvelt A.   +12 more
europepmc   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Intranasal delivery of iron chelators and management of central nervous system disease. [PDF]

Front Pharmacol
Cheng R, Kim J.
europepmc   +1 more source

Characterization of the biodistribution profile of a human Dialyzable Leukocyte Extract (hDLE) by <i>in vivo</i> fluorescence imaging: a strategy to infer the ADME profile of complex multipeptide drugs. [PDF]

Front Pharmacol
Fragozo A, Trejo-Martínez I, Domínguez-Bernal K, Valencia-Flores L, Macias-Palacios Z, Pavón L, Pérez-Torres A, Aguilar-Alonso FA, Vázquez-Leyva S, Vallejo-Castillo L, Pérez-Tapia SM.   +10 more
europepmc   +1 more source

A high content (30%) stable doxycycline hyclate drinking-water solution for broilers: preparation, stability, and bioequivalence. [PDF]

Front Vet Sci
Liu Z, Jiao X, Xie L, Ren W, Lv L, Du J, Huang X.   +6 more
europepmc   +1 more source

Lipid-Enriched Gintonin from Korean Red Ginseng Marc Alleviates Obesity via Oral and Central Administration in Diet-Induced Obese Mice. [PDF]

Nutrients
Yasmin T, Lee Y, Kim WS, Lee B, Lee R, Hwang H, Nam MH, Nah SY, Kim MS, Rhim H.   +9 more
europepmc   +1 more source

Strategies for overcoming multiple barriers of oral administration of protein and peptide therapeutics. [PDF]

Mater Today Bio
Wang X, Wang K, Fang Y, Zhang Y, Yi L, Li X, Zhao Q, Zhu X, Cai S, Wan L.   +9 more
europepmc   +1 more source

3D-Printed Oral Disintegrating Films of Brain-Targeted Acetyl Salicylic Acid Nanoparticles for Enhanced CNS Delivery in Ischemic Stroke. [PDF]

Pharmaceutics
Pasupuleti D, D'Souza M, Ferguson A, Gulani MA, Patel P, Singh R, Adediran E, Vijayanand S, Arte TM, D'Souza M.   +9 more
europepmc   +1 more source