Results 241 to 250 of about 1,808,839 (310)

Efficacy of tenoxicam for postoperative dental pain: a systematic review of randomized controlled trials. [PDF]

J Dent Anesth Pain Med
Altuhafy M, Kamdar D, Khan J.
europepmc   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

A Phase 1 Multiple-Dose, Open-Label, Pharmacokinetic Study of Nirmatrelvir/Ritonavir in Healthy Lactating Women. [PDF]

Clin Transl Sci
Gerhart J, Cheruvu N, Pelletier K, Matschke K, Shi H, Mfopou JK, Hammond J, Singh RSP.   +7 more
europepmc   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Gastric and rectal administration of encorafenib with targeted chemotherapy against BRAF V600E-mutant rectal cancer with bowel obstruction. [PDF]

Oncologist
Funk MA, Heinemann V, Bücklein V, Alig SK, Heinrich K, Weiss L, Krenmayr V, Blanchet B, Kunz WG, Theurich S, von Bergwelt-Baildon M, Holch JW.   +11 more
europepmc   +1 more source

Effect of High-Dose Oral Insulin in Children With Stage 1 Type 1 Diabetes: The Fr1da Insulin Intervention Randomized Controlled Trial. [PDF]

Diabetes Care
Ziegler AG, Albeer A, Arnolds S, Assfalg R, Bunk M, Daniel C, Hofelich A, Jacobsen S, Kick K, Knoop J, Kohls M, Kordonouri O, Matzke C, Pfirrmann M, Ramminger C, Sarcletti K, Scholz M, Schütte-Borkovec K, Serr I, Weigelt M, Weiss A, Winkler C, Bonifacio E, Achenbach P.   +23 more
europepmc   +1 more source

Absolute Bioavailability and Absorption, Distribution, Metabolism, and Excretion of [¹⁴C]Xevinapant, a Potent, Oral, Small-Molecule IAP Inhibitor. [PDF]

Clin Pharmacol Drug Dev
Menetrey A, Nicolas-Metral V, Roubaudi-Fraschini MC, Tat T, Zhao Y, Vugmeyster Y, Venkatakrishnan K, Rohdich F, Scheible H.   +8 more
europepmc   +1 more source

Pharmacokinetics, Pharmacodynamics, Efficacy and Drug Resistance Selection of Injectable Long-Acting Lenacapavir Pre-Exposure Prophylaxis (PrEP) Against HIV. [PDF]

CPT Pharmacometrics Syst Pharmacol
Kim HY, Liebenberg A, Zhang L, von Kleist M.   +3 more
europepmc   +1 more source

Emergency Department Visits and Hospitalizations for Unintentional Exposures to Oral Prescription Medications Among Young Children. [PDF]

JAMA Pediatr
Daubresse M, Seitz AE, Ho A, Lee R, Lovegrove MC, Geller AI, Lyles JL, Meyer TE.   +7 more
europepmc   +1 more source