Results 221 to 230 of about 3,926,222 (296)

Experimental Immunogenicity and Multi-Region Field Performance of a Briquette-Formulated Oral Rabies Vaccine Bait in Kazakhstan. [PDF]

Biology (Basel)
Toktyrova D, Abitayev R, Ussembay A, Amanova Z, Sametova Z, Turyskeldy S, Kondibayeva Z, Kurmasheva A, Koshemetov Z, Renukaradhya GJ, Kistaubayeva A, Mazbayeva D, Bulatov Y.   +12 more
europepmc   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

Probiotic intervention modulates volatile sulfur compound-associated pathways and oral microbiome balance in ligature-induced periodontitis rats. [PDF]

J Oral Microbiol
Haque MA, Kim H, Moon JS, Sim SR, Razzak MA, Song S, Jeon JI, Park MS, Ku S.   +8 more
europepmc   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Genetically defined systemic autoinflammatory diseases in pediatric patients with Behçet's disease. [PDF]

Front Immunol
Zheng S, Lee PY, Zhou Q, Han X, Huang X, Huang Y, Chen J, Zheng C, Fang X, Yu J, Wang A, Pan X, Yu X, Li T.   +13 more
europepmc   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Lead Validation of the Olive Phenolic <i>S</i>-(-)-Oleocanthal for Effective Control of <i>KRAS^G13D</i>-Mutant Colorectal Cancer Progression and Metastasis. [PDF]

Nutrients
Tarun MTI, Ebrahim HY, El Sayed KA.
europepmc   +1 more source

Sublingual Administration for Pain Control: Pharmacology, Clinical Applications and Future Directions. [PDF]

CNS Drugs
Koushik SS, Gritsenko K, Binda DD, Daybell IS, Hill NS, Raghavan J, Borukh E, Smith BB, Kraus M, Shaparin N.   +9 more
europepmc   +1 more source

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin. [PDF]

Clin Pharmacol Ther
Shaul C, Mujahed W, Idries I, Wanounou M, Bialer M, Caraco Y.   +5 more
europepmc   +1 more source

Bioactive goldenseal (Hydrastis canadensis) fraction suppresses multidrug-resistant Pseudomonas aeruginosa in a rat burn wound model: oral and topical administration. [PDF]

Sci Rep
Turkey MS, Nazeam JA, Sherbiny FF, Alnasser SM, Abdo W, Al-Noshokaty TM, Abass SA.   +6 more
europepmc   +1 more source