Results 121 to 130 of about 9,197,462 (314)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
NATIONAL CURRENCY INSTABILITY [PDF]
The concept related to currency stability includes internal currency stability as intern price stability, the money demand and supply stability and the stability of the interest rate.
Gherman Anca Maria, Huru Dragos
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
İşveren Markasının İnsan Kaynakları Süreçleri Üzerine Etkileri
Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2019 Küreselleşme sürecinin etkilerinin arttığı işgücü piyasalarında, şirketler için büyük önem arz eden konuların başında gelen İnsan Kaynakları Yönetimi; şirketin gelecek hedeflerine ulaşabilmesi, şirket verimliliğinin sağlanması ve artırılması için ihtiyaç
Mehmet Güler
doaj
THEORETICAL GROUNDS FOR SOME MAIN ISSUES OF THE INTEGRATED EUROPE AND OF THE KNOWLEDGE BASED ECONOMY IN THE ROMANIAN ECONOMIC THOUGHT [PDF]
Paper underlines some essential elements of the economic thought of some most important Romanian economists of the 20th century, reconsidering them in the actual European knowledge society.Methodologically, the paper resorts to the roots of the ...
Jivan Alexandru
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
CREATIVE ECONOMY. DETERMINANTS AND STAKES OF CREATIVITY AND INNOVATION MANAGEMENT. REGIONAL INGRESSIONS [PDF]
Within the framework of creative economy the creative and innovative management represents a strategic issue to consider when stimulating the enhancement of competitiveness among companies and countries.
IVANOVICI MINA +2 more
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source