Results 141 to 150 of about 5,527,372 (361)
Administration of José Ballivián in Bolivia [PDF]
Ethel M. Crampton, Laura F. Ullrick
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TRPM8 levels determine tumor vulnerability to channel agonists
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo+18 more
wiley +1 more source
REPORT OF THE LANCET COMMISSION APPOINTED TO INVESTIGATE THE SUBJECT OF THE ADMINISTRATION OF CHLOROFORM AND OTHER ANÆSTHETICS FROM A CLINICAL STANDPOINT. [PDF]
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The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine+10 more
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Diffuse Lepra**From the Birmingham Veterans Administration Hospital, Van Nuys, Calif.
Maximilian E. Obermayer+2 more
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In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton+17 more
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The Book of common prayer : and administration of the sacraments, and other rites and ceremonies of the church, according to the use of the Church of England : together with the Psalter or Psalms of David, pointed as they are to be sung or said in churches [PDF]
John Baskerville, Anton Briscom
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Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed+8 more
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ACCIDENTAL INTRA-ARTERIAL ADMINISTRATION OF THIOPENTONE ON THE BACK OF THE HAND
T. W. Baillie
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Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho+11 more
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