Results 261 to 270 of about 9,451,716 (342)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Thailand Insurance TPA Market: Optimizing Claims and Healthcare Administration Through Technology and Regulatory Support

next move strategy consulting
openalex   +1 more source

Mucoadhesive In Situ Gelling Liquid Crystalline Precursor System to Improve the Vaginal Administration of Drugs

, 2019
Patricia Rocha de Araújo, Giovana Calixto, Isabel C. Silva, Lucas Henrique de Paula Zago, João Augusto Oshiro, Fernando R. Pavan, Anderson Orzari Ribeiro, Carla Raquel Fontana, Marlus Chorilli   +8 more
openalex   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Living sensor display implanted on skin for long-term biomarker monitoring. [PDF]

Nat Commun
Sawayama J, Takeo M, Takayama Y, Takase M, Aoyagi H, Takimoto A, Mizutani S, Onuki M, Ikeo S, Nagata S, Ogawa M, Yano K, Tsuji T, Takeuchi S, Fujita H.   +14 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Correction: Insulin-self administration among individuals with diabetes: Implications for improved practices. [PDF]

PLoS One
Jarab AS, Al-Qerem WA, Alqudah S, Alzoubi KH, Abu Heshmeh SR, Al Hamarneh YN, Alefishat E, Mimi Y, Khdour M.   +8 more
europepmc   +1 more source

CHALLENGES OF TAX ADMINISTRATION: THE CASE OF MACHAKL WOREDA Revenue office, East Gojjam Amahara Ethiopia.

Abew Tiruneh
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correction: Case series: Effects of a ketogenic diet on cardiometabolic health in seven outpatients with bipolar disorder. [PDF]

Front Nutr
Schreel L, Bürkle M, Thiem A, von Baehr V, Sauren J, Keferstein G.   +5 more
europepmc   +1 more source