Results 71 to 80 of about 643,499 (354)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Phage Therapy for Bone and Joint Infections: Towards Clinical Translation

Antibiotics
Osteoarticular infections (OAIs), including osteomyelitis, septic arthritis, prosthetic joint infections, and facture-related infections, remain a major challenge due to biofilm formation and the prevalence of multidrug-resistant (MDR) pathogens ...
Concha Ortiz-Cartagena, Lucia Blasco, Inés Bleriot, Jaime Esteban, María Dolores del Toro, José Luis del Pozo, María Tomás   +6 more
doaj   +1 more source

Nanoparticle drug delivery systems for inner ear therapy: An overview [PDF]

, 2017
open7noembargoed_20180701Valente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini, AlessandroValente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini,
Astolfi, Laura, Chicca, Milvia, DANTI, SERENA, Franceschini, Valeria, Martini, Alessandro, Simoni, Edi, Valente, Filippo   +6 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Analysis and comparison of adverse events of colistin administered by different routes based on the FAERS database

Scientific Reports
Objective: To analyze and compare the incidence of adverse events (AEs) associated with different administration routes of colistin, with the aim of providing a reference for its safe and effective clinical use.
Pengtao Xu, Lili Xu, Hui Ji, Yibo Song, Keying Zhang, Xiuying Ren, Zhihua Tang   +6 more
doaj   +1 more source

Therapeutic efficacy of nanoparticles and routes of administration

Biomaterials Research, 2019
In modern-day medicine, nanotechnology and nanoparticles are some of the indispensable tools in disease monitoring and therapy. The term “nanomaterials” describes materials with nanoscale dimensions (
Dhrisya Chenthamara, Sadhasivam Subramaniam, Sankar Ganesh Ramakrishnan, Swaminathan Krishnaswamy, Musthafa Mohamed Essa, Feng-Huei Lin, M. Walid Qoronfleh   +6 more
doaj   +1 more source

Effect of administration route on the biodistribution of albumin microspheres labelled with Re-188 [PDF]

, 2021
В. К. Тищенко, В. М. Петриев, О. П. Власова, Е. Д. Степченкова   +3 more
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Relación e impacto del consumo de sustancias psicoactivas sobre la salud en Colombia (Relationship and Impact of the Use Psychoactive Substances on Health in Colombia) [PDF]

Liberabit, 2013
RESUMEN: Esta investigación tuvo como objetivo principal realizar una aproximación preliminar al examen de la relación entre el consumo de drogas y los problemas de salud en Colombia. Para ello se utilizó un cuestionario con 11 categorías de enfermedades
Adriana Marcela Correa Muñoz, Augusto Pérez Gómez   +1 more
doaj  

Polysaccharide based formulations for mucosal drug delivery: A review [PDF]

, 2015
There has been increased interest in novel drug delivery systems to be administered via mucosal routes as an alternative to the currently used traditional routes such as parenteral (injections) and oral routes of administration.
Boateng, Joshua, Khan, Sajjad, Okeke, Obinna   +2 more
core   +1 more source