Results 41 to 50 of about 2,910,042 (163)
The Condition of College & Career Readiness 2012: Hispanic Students
, 2019 Using ACT test scores and the ACT College Readiness Benchmarks, The Condition of College & Career Readiness 2012 provides a series of graphics highlighting the college and career readiness of the ACT-tested high school class of 2012.
ACT
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Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
The Condition of College & Career Readiness 2018
, 2019 This report looks at the progress of the ACT®-tested 2018 US high school graduating class relative to college and career readiness. The data in this report are based on more than 1.9 million graduates—55% of the students in the 2018 national graduating ...
ACT
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
ADMINISTRATIVE CONVERGENCE AND REFORMS IN SOUTH-EASTERN EUROPEAN STATES - Analyses, models and comparative studies [PDF]
The fundamental idea of the current publication emphasizes the characteristics of the processes related to administrative convergence and reform in the South-Eastern European states. Of course the area under review is quite wide and complex and therefore
Ani Matei, Panagiotis Grigoriou
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Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The Condition of College and Career Readiness 2015: Pacific Islander Students
, 2019 The Condition of College & Career Readiness 2015 is the ACT annual report on the progress of US high school graduates relative to college readiness. This year’s report shows that 59% of students in the 2015 US graduating class took the ACT® test, up from
ACT
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source