Results 61 to 70 of about 1,567,491 (311)

Endangered Species Act Innovations in the Post-Babbittonian Era—Are There Any? [PDF]

open access: yes, 2004
One of the mysteries of environmental policy in the Bush Administration will be how and why it squandered an opportunity to continue market-based administrative reforms of the Endangered Species Act begun, ironically, in the Clinton Administration under ...
Ruhl, J. B.
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

The Effectiveness Of Administrative Review In Indonesia’S Administrative Court System

open access: yesProphetic Law Review, 2019
This research aims to describe the use of administrative review in Indonesia. There are two rules of administrative review: administrative review according to Act Number 5 Year 1986 on State Administrative Judicial Action, and administrative review ...
Umar Dani
doaj   +1 more source

The impact of the 2006-07 HE finance reforms on HE participation (BIS research paper no.13) [PDF]

open access: yes, 2010
"This report examines the effects of the package of reforms introduced by the Higher Education Act in 2006-07 on HE participation, using administrative data on all state school students in England, linked to HE records from all UK universities.
Crawford, Claire, Dearden, Lorraine
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

The West German Administrative Procedure Act: A Study in Administrative Decision Making [PDF]

open access: yes, 1984
This Article examines the West German Administrative Procedure Act ( VwVfG ), which forms an essential element in the German model of administrative decision-making and provides valuable insight into the nature of administrative decision-making in ...
Eberle, Edward J.
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Building Consensus and Partnerships for Implementing the MAP-21 Section 5310 Program in California, MTI Report WP 12-25 [PDF]

open access: yes, 2014
The Moving Ahead for Progress in the 21st Century Act (MAP-21)—the legislation that currently provides funding for federal transportation—allows metropolitan planning organizations (MPOs) or eligible large, urbanized area (UZA) agencies to assume ...
Appleyard, Bruce, Ferrell, Christopher
core   +1 more source

Does practice make perfect? Debate about principles versus practice in New Zealand local government planning [PDF]

open access: yes, 1999
Legislation and practice are two arms of public policy planning. Legislation empowers or enables; practice is the articulation and implementation of legislative principle.
Jay, Grace Mairi M.
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

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