Results 81 to 90 of about 1,553,975 (340)
Which Institution Should Determine Whether an Agency’s Explanation of a Tax Decision is Adequate?: A Response to Steve Johnson [PDF]
, 2014 This Essay responds to Professor Steve Johnson’s Article for the 2014 Duke Law Journal Administrative Law Symposium, Reasoned Explanation and IRS Adjudication.
Pierce, Richard J., Jr
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Pertanggungjawaban Pejabat Administrasi Negara dalam Hal Terjadinya Kerugian pada Keuangan Negara dalam Kasus Tindak Pidana Korupsi [PDF]
, 2012 Lots of administration officials act committed by state administrative decisions later on declared as a criminal act of corruption because there is evidence that a state administrative decision is causing loss to the economy or finance.
Nodi, H. (Hamzar)
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Suspensive effect of claim in administrative dispute [PDF]
Zbornik Radova: Pravni Fakultet u Novom SaduThe subject of this paper is the suspensive effect of a claim in an administrative dispute - in comparative and domestic law. Comparative law analysis includes German and Austrian law, having in mind that Serbian judicial control of administration is the
Milkov Dragan L., Radošević Ratko S.
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
EIRP Proceedings, 2011 The preliminary procedure is an administrative non-contentious procedure, textualy stated by article 7(1) of LCA Act, that provides for the person that considers himself to be harmed in relation to an individual right or legitimate interest of his own ...
Andreea Diana Papa
doaj
Why Michigan v. EPA Requires that the Meaning of the Cost/Rationality Nexus Be Clarified [PDF]
, 2017 This article examines the recent decision in Michigan v. EPA, in which the U.S. Supreme Court held that the EPA acted unreasonably in not considering costs at the listing phase of the regulation of power plants’ emissions under a specific provision of ...
Arlota, Carolina, Bertolini, Daniele
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Suggestions on Perfecting the Legality Review System of Administrative Act [PDF]
, 2018 Longyu Wang, Hanke Li, Tianchong Yao
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