Results 111 to 120 of about 409,452 (309)

Investigating setting-specific superspreading potential and generation intervals of COVID-19 in Hong Kong

Nature Communications
Superspreading is an important feature of COVID-19 transmission dynamics, but few studies have investigated this feature stratified by transmission setting. Using detailed clustering data comprising 8647 COVID-19 cases confirmed in Hong Kong between 2020
Dongxuan Chen, Dillon C. Adam, Yiu-Chung Lau, Dong Wang, Wey Wen Lim, Faith Ho, Tim K. Tsang, Eric H. Y. Lau, Peng Wu, Jacco Wallinga, Benjamin J. Cowling, Sheikh Taslim Ali   +11 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Non-pharmaceutical interventions to reduce influenza transmission in households: a systematic review and meta-analysis

International Journal of Infectious Diseases
Background: Influenza pandemic plans often recommend non-pharmaceutical interventions (NPIs) in household settings, including hand hygiene and face masks.
Jessica Y. Wong, Wey Wen Lim, Justin K. Cheung, Caitriona Murphy, Eunice Y.C. Shiu, Jingyi Xiao, Dongxuan Chen, Yanmin Xie, Mingwei Li, Hualei Xin, Michelle Szeto, Sammi Choi, Benjamin J. Cowling   +12 more
doaj   +1 more source

Administrative Transaction Data [PDF]

The value of administrative transaction data, such as financial transactions, credit card purchases, telephone calls, and retail store scanning data, to study social behaviour has long been recognised.
Julia Lane
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Wartime Civil Control Administration administrative order #2

, 1942
An administrative order that outlined a new process for procuring supplies, equipment, and personnel for the Wartime Civil Control Administration. The order details appropriate forms and procedures for procuring supplies, equipment, printing, processing,
Bendetsen, Karl R.: author; Wartime Civil Control Administration: author
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Wartime Civil Control Administration administrative order #8

, 1942
An administrative order that superseded administrative order #2 in regards to copies or mimeograph services. This new order outlines the procedure for ordering mimeograph stencils and other supplies for copies.
Bendetsen, Karl R.: author; Wartime Civil Control Administration: author
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

ADMINISTRATIVE CONVERGENCE AND REFORMS IN SOUTH-EASTERN EUROPEAN STATES - Analyses, models and comparative studies [PDF]

The fundamental idea of the current publication emphasizes the characteristics of the processes related to administrative convergence and reform in the South-Eastern European states. Of course the area under review is quite wide and complex and therefore
Ani Matei, Panagiotis Grigoriou
core