Results 71 to 80 of about 24,850,578 (311)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mapping the dynamics between violence and alcohol outlets in Scotland using data from ambulance services.

International Journal of Population Data Science
Objective In Scotland, the link between alcohol consumption and violent crime remains a significant concern. This study aims to explore the association between assault-related incidents captured by health services in Scotland and the availability and ...
Susan McVie, Ana Morales-Gomez
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Utah Administrative Code 1989, Volume 4

, 1987
Series 83623 | Utah Division of Administrative Rules | Utah Administrative Code | Utah Administrative Code 1989, Volume 4The Utah Administrative Code is the authorized compilation of the administrative law of Utah (See Utah Code Section 63-46a-16 (1987 ...
Utah Division of Administrative Rules
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Utah Administrative Code 1987-1988, Volume 2

, 1987
Series 83623 | Utah Division of Administrative Rules | Utah Administrative Code | Utah Administrative Code 1987-1988, Volume 2The Utah Administrative Code is the authorized compilation of the administrative law of Utah (See Utah Code Section 63-46a-16 ...
Utah Division of Administrative Rules
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Intellectual and Physical Disability and Risk of COVID-19 Infection, Hospitalisation, and Mortality: A National Cohort of 3.7 Million Adults in Scotland

Journal of Epidemiology and Global Health
Background Disabled people experienced disproportionately poor outcomes during the COVID-19 pandemic, but evidence remains uneven across disability status and across stages of the disease pathway.
Yusuff Adebayo Adebisi, Nick Bailey, Angela Henderson, Chris Dibben, Serena Pattaro   +4 more
doaj   +1 more source

Utah Administrative Code 1989, Volume 3

, 1989
Series 83623 | Utah Division of Administrative Rules | Utah Administrative Code | Utah Administrative Code 1989, Volume 3The Utah Administrative Code is the authorized compilation of the administrative law of Utah (See Utah Code Section 63-46a-16 (1987 ...
Utah Division of Administrative Rules
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source