Results 51 to 60 of about 231,670 (307)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

SOCIAL CONDITIONALITY OF ADMINISTRATIVE PREJUDICE IN THE CRIMINAL LAW OF RUSSIA

National Association of Scientists, 2021
Modern criminal legislation of the Russian Federation needs institutions that contribute to the humanization of criminal law. One of such institutions, actively discussed in the scientific legal community, is the administrative prejudice, which, due to its legislative structure, forms a ban on the commission of certain actions enshrined in the criminal
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Formation of a doctrinal approach to public danger as a sign of crimes and administrative offenses

Правоприменение
The purpose of the scientific article is to, based on an analysis of the concept and essence of public danger, offer scientifically based conclusions related to the understanding of whether acts should be differentiated on the grounds of “nuisance” and ...
A. N. Alexandrov, O. A. Dizer, T. A. Nedostypenko   +2 more
doaj   +1 more source

On Preventive Potential of Norms with Administrative Prejudice

Oeconomia et Jus
When criminalizing socially dangerous acts of minor severity, the legislator increasingly uses the norms with administrative prejudice, since their application allows preventing more serious criminal acts and negative social phenomena in society. At the same time, the preventive potential of the norms with administrative prejudice has not yet been ...
Valeriy Ph. Anisimov, Natalya Yu. Akinina, Anastasia A. Berndt   +2 more
openaire   +1 more source

INSTITUTION OF ADMINISTRATIVE PREJUDICE IN CRIMINAL CODE OF RUSSIAN FEDERATION

Yugra State University Bulletin, 2017
This article analyses reasons for the return of Russian lawmakers to the Institution of administrative prejudice. Such reasons are carrying out a liberal policy of criminal legislation and the possibility of crime prevention through administrative penalties.
Natalia Yu Akinina, Alexander A Berndt
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Public danger of the individual and the basis of criminalization [PDF]

Пенитенциарная наука
Introduction: an analysis of the novelties of the Special Part of the Criminal Code over the past decade shows that the absolute majority of them are special norms, in fact, aimed not at establishing liability for a particular act, but at ...
Karavaeva Yu.S.
doaj   +1 more source

Cultural Competency in a Post-Model Rule 8.4(g) World [PDF]

, 2014
Självmord är en av de vanligaste dödsorsakerna i Sverige. Personer som begått självmord lämnar efter sig närstående med en stor sorg. Syftet med studien var att undersöka huruvida närstående till personer som begått självmord får det stöd som de önskar ...
Haraldsson, Ingeborg, Jacobsson, Jennifer   +1 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source