Results 61 to 70 of about 231,670 (307)

Home advantage: the experience of home-educated students in English higher education and recommendations for new “WISE” practices [PDF]

open access: yesQuality Education for All
Purpose – The purpose of this study is to understand some of the opportunities and barriers that students with home education experience meet in entering and participating in higher education (HE) in England.
Lou Graham   +2 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

The Legislation on Administrative Offenses: Reform or Modernization

open access: yesСибирское юридическое обозрение, 2017
The article examines the state of legislation on administrative offenses. The necessity of modernization, ideas and prospects for the development and adoption of a new codified legal act in the relevant legal sphere is argumented.
Aleksandr G. Avdeiko, Dmitrii A. Gazizov
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

IDENTIFYING THE RIGHT OF A PERSON AGGRIEVED BY A PUBLIC AUTHORITY IN THE ROMANIAN CONSTITUTION AND IN COMPARATIVE LAW [PDF]

open access: yesChallenges of the Knowledge Society, 2018
The purpose of the present study is to analyze the development and the evolution of the right of a person aggrieved by a public authority in the Romanian Constitutions and in comparative law.
Cătălin-Radu PAVEL
doaj  

Perceptions of Malaysian medical students from different academic years on primary care: a qualitative research

open access: yesFamily Medicine and Community Health, 2020
Objective To explore the perception of medical students from a private medical college in Perak, Malaysia, on primary care practice and induce the factors influencing their perception and willingness to consider primary care as a career pathway.Design ...
Sook Ching Chan   +3 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Empirical Perspectives on Mediation and Malpractice [PDF]

open access: yes, 1997
The use of mediation in the medical malpractice context is examined.
Metzloff, Thomas B.   +2 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

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