Results 171 to 180 of about 6,498,853 (379)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

تحليل إجراءات الطعن الإداري وأثرها على العدالة الإدارية في ظل القانون الإداري المصري والإماراتي Analysis of administrative appeal procedures and their impact on administrative justice under Egyptian and UAE administrative law [PDF]

رغدة رافت السيد
openalex   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Antecedents of Patient Loyalty: Exploring Mediating and Moderating Paradigms in Public Hospitals

Patient Preference and Adherence
Abid Hussain,1 Shahida Kanwel,2 Sania Khan,3 Wadi B Alonazi,4 Azam Malik,3 Ali Ahmed Khan5 1School of Nursing, Shandong Xiehe University, Jinan, 250109, People’s Republic of China; 2School of Management, Jiangsu University, Zhenjiang, Jiangsu, 212013 ...
Hussain A, Kanwel S, Khan S, Alonazi WB, Malik A, Khan AA   +5 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A cross-sectional study on the impact of administrative procedures and medical staff services on patient satisfaction with trust in public sector hospitals: the moderating role of e-health knowledge. [PDF]

BMC Health Serv Res
Hussain A, Ruowei W, Xia X, Jameel A, Chunhong S, Ahmad S.   +5 more
europepmc   +1 more source

: <br>Lifting Criminal Procedure Barriers: Decreasing Administrative Power and Reinforcing Judicial Review

, 2017
Asaf Harduf
openalex   +1 more source

Administrative Machinery and Procedures for Renegotiation [PDF]

, 1943
Boyd, Paul B.
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

New Zealand Electronic Health Data for Cardiovascular Research: A Review. [PDF]

Clin Epidemiol
Møller AE, Jackson R, Kerr AJ, Wells S, Poppe KK, Schmidt M.   +5 more
europepmc   +1 more source