Results 111 to 120 of about 1,905,858 (334)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
DECISION IN ADMINISTRATIVE PROCEEDINGS
Scientific Journal of the Military University of Land Forces, 2011 The article analyses adjudication processes: decision-making, incentives, factual states and legal conditions influencing the content of adjudication. A practical solution to problems by adjudication and a custom as part of this practice. A custom can be defined as a non-legal habit of conduct virtually observed within a given organizational structure (
openaire +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Types and legal status of persons involved in cases of economic administrative offenses [PDF]
, 2014 Салманова, О. Ю. Види та правовий статус осіб, які беруть участь у справах про господарські адміністративні правопорушення / О. Ю. Салманова // Науковий вісник Ужгородського національного університету : Серія: Право. – Ужгород: Видавничий дім «Гельветика»
ORCID: http://orcid.org/0000-0002-6376-1160 +2 more
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Studia Prawa Publicznego, 2018 The aim of the article is to explain the reasons for the introduction of mediation in administrative law. Mediation is presented in the light of the Recommendation of the Committee of the Council of Ministers R (2001)9 of 5 September 2001 on ...
Bartłomiej Chludziński
doaj +1 more source
Decision-making in administrative proceeding [PDF]
Zbornik radova Pravnog fakulteta, Novi Sad, 2015 Administrative decision-making by official who conducting the administrative procedure may have a number of advantages over the decisionmaking by the senior official which manages by the administrative authority. However, to make that such a novelty have positive effects, it is necessary, next to the amendments to the Law on Administrative Procedure ...
openaire +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Die reg op regsverteenwoordiging tydens administratiewe verrigtinge [PDF]
Potchefstroom Electronic Law Journal, 2004 THRE RIGHT TO LEGAL REPRESENTATION DURING ADMINISTRATIVE PROCEEDINGSThe question whether a person is entitled to legal representation is normally posed during disciplinary proceedings, but is also relevant to other types of administrative proceedings. No
MC Roos
doaj